Serum Bilirubin Levels in Overweight and Obese Individuals: The Importance of Anti-Inflammatory and Antioxidant Responses

被引：30
作者：
Ziberna, Lovro [1 ]
Jenko-Praznikar, Zala [2 ]
Petelin, Ana [2 ]
机构：
[1] Univ Ljubljana, Fac Med, Inst Pharmacol & Expt Toxicol, SI-1000 Ljubljana, Slovenia
[2] Univ Primorska, Fac Hlth Sci, SI-6310 Izola, Slovenia
来源：
ANTIOXIDANTS | 2021年 / 10卷 / 09期
关键词：
adipokines; antioxidant; anti-inflammatory; bilirubin; obesity; overweight; NECROSIS-FACTOR-ALPHA; CONSTITUTIVE ANDROSTANE RECEPTOR; PROLIFERATOR-ACTIVATED RECEPTOR; IMPROVES INSULIN SENSITIVITY; HUMAN FAT-CELLS; ADIPOSE-TISSUE; OXIDATIVE STRESS; METABOLIC SYNDROME; HEME OXYGENASE; CHRONIC INFLAMMATION;
D O I：
10.3390/antiox10091352
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Obesity is a chronic condition involving low-grade inflammation and increased oxidative stress; thus, obese and overweight people have lower values of serum bilirubin. Essentially, bilirubin is a potent endogenous antioxidant molecule with anti-inflammatory, immunomodulatory, antithrombotic, and endocrine properties. This review paper presents the interplay between obesity-related pathological processes and bilirubin, with a focus on adipose tissue and adipokines. We discuss potential strategies to mildly increase serum bilirubin levels in obese patients as an adjunctive therapeutic approach.
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页数：16
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