Serum Bilirubin Levels in Overweight and Obese Individuals: The Importance of Anti-Inflammatory and Antioxidant Responses

被引：30
作者：
Ziberna, Lovro [1 ]
Jenko-Praznikar, Zala [2 ]
Petelin, Ana [2 ]
机构：
[1] Univ Ljubljana, Fac Med, Inst Pharmacol & Expt Toxicol, SI-1000 Ljubljana, Slovenia
[2] Univ Primorska, Fac Hlth Sci, SI-6310 Izola, Slovenia
来源：
ANTIOXIDANTS | 2021年 / 10卷 / 09期
关键词：
adipokines; antioxidant; anti-inflammatory; bilirubin; obesity; overweight; NECROSIS-FACTOR-ALPHA; CONSTITUTIVE ANDROSTANE RECEPTOR; PROLIFERATOR-ACTIVATED RECEPTOR; IMPROVES INSULIN SENSITIVITY; HUMAN FAT-CELLS; ADIPOSE-TISSUE; OXIDATIVE STRESS; METABOLIC SYNDROME; HEME OXYGENASE; CHRONIC INFLAMMATION;
D O I：
10.3390/antiox10091352
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Obesity is a chronic condition involving low-grade inflammation and increased oxidative stress; thus, obese and overweight people have lower values of serum bilirubin. Essentially, bilirubin is a potent endogenous antioxidant molecule with anti-inflammatory, immunomodulatory, antithrombotic, and endocrine properties. This review paper presents the interplay between obesity-related pathological processes and bilirubin, with a focus on adipose tissue and adipokines. We discuss potential strategies to mildly increase serum bilirubin levels in obese patients as an adjunctive therapeutic approach.
引用
收藏
页数：16
相关论文
共 132 条
  • [1] Leptin
    Ahima, RS
    Flier, JS
    [J]. ANNUAL REVIEW OF PHYSIOLOGY, 2000, 62 : 413 - 437
  • [2] Acute effect of weight loss on levels of total bilirubin in obese, cardiovascular high-risk patients: an analysis from the lead-in period of the Sibutramine Cardiovascular Outcome trial
    Andersson, Charlotte
    Weeke, Peter
    Fosbol, Emil Loldrup
    Brendorp, Bente
    Kober, Lars
    Coutinho, Walmir
    Sharma, Arya M.
    Van Gaal, Luc
    Finer, Nick
    James, W. Philip T.
    Caterson, Ian D.
    Rode, Richard A.
    Torp-Pedersen, Christian
    [J]. METABOLISM-CLINICAL AND EXPERIMENTAL, 2009, 58 (08): : 1109 - 1115
  • [3] BAIRD IM, 1981, INT J OBESITY, V5, P249
  • [4] Association of Serum Bilirubin Level with Metabolic Syndrome and Non-Alcoholic Fatty Liver Disease: A Cross-Sectional Study of 1672 Obese Children
    Bellarosa, Cristina
    Bedogni, Giorgio
    Bianco, Annalisa
    Cicolini, Sabrina
    Caroli, Diana
    Tiribelli, Claudio
    Sartorio, Alessandro
    [J]. JOURNAL OF CLINICAL MEDICINE, 2021, 10 (13)
  • [5] Body Fat Percentage Is a Major Determinant of Total Bilirubin Independently of UGT1A1*28 Polymorphism in Young Obese
    Belo, Luis
    Nascimento, Henrique
    Kohlova, Michaela
    Bronze-da-Rocha, Elsa
    Fernandes, Joao
    Costa, Elisio
    Catarino, Cristina
    Aires, Luisa
    Mansilha, Helena Ferreira
    Rocha-Pereira, Petronila
    Quintanilha, Alexandre
    Rego, Carla
    Santos-Silva, Alice
    [J]. PLOS ONE, 2014, 9 (06):
  • [6] BREIMER LH, 1995, CLIN CHEM, V41, P1504
  • [7] Adipocyte Heme Oxygenase-1 Induction Attenuates Metabolic Syndrome in Both Male and Female Obese Mice
    Burgess, Angela
    Li, Ming
    Vanella, Luca
    Kim, Dong Hyun
    Rezzani, Rita
    Rodella, Luigi
    Sodhi, Komal
    Canestraro, Martina
    Martasek, Pavel
    Peterson, Stephen J.
    Kappas, Attallah
    Abraham, Nader G.
    [J]. HYPERTENSION, 2010, 56 (06) : 1124 - U246
  • [8] Dietary factors and low-grade inflammation in relation to overweight and obesity
    Calder, Philip C.
    Ahluwalia, Namanjeet
    Brouns, Fred
    Buetler, Timo
    Clement, Karine
    Cunningham, Karen
    Esposito, Katherine
    Jonsson, Lena S.
    Kolb, Hubert
    Lansink, Mirian
    Marcos, Ascension
    Margioris, Andrew
    Matusheski, Nathan
    Nordmann, Herve
    O'Brien, John
    Pugliese, Giuseppe
    Rizkalla, Salwa
    Schalkwijk, Casper
    Tuomilehto, Jaakko
    Waernberg, Julia
    Watzl, Bernhard
    Winklhofer-Roob, Brigitte M.
    [J]. BRITISH JOURNAL OF NUTRITION, 2011, 106 : S1 - S78
  • [9] The Macrophage Switch in Obesity Development
    Castoldi, Angela
    de Souza, Cristiane Naffah
    Saraiva Camara, Niels Olsen
    Moraes-Vieira, Pedro M.
    [J]. FRONTIERS IN IMMUNOLOGY, 2016, 6
  • [10] Adiponectin stimulates production of nitric oxide in vascular endothelial cells
    Chen, H
    Montagnani, M
    Funahashi, T
    Shimomura, I
    Quon, MJ
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (45) : 45021 - 45026
12345678910