Serum Bilirubin Levels in Overweight and Obese Individuals: The Importance of Anti-Inflammatory and Antioxidant Responses

被引：37

作者：

Ziberna, Lovro ^{[1
]}

Jenko-Praznikar, Zala ^{[2
]}

Petelin, Ana ^{[2
]}

机构：

[1] Univ Ljubljana, Fac Med, Inst Pharmacol & Expt Toxicol, SI-1000 Ljubljana, Slovenia

[2] Univ Primorska, Fac Hlth Sci, SI-6310 Izola, Slovenia

来源：

ANTIOXIDANTS | 2021年 / 10卷 / 09期

关键词：

adipokines; antioxidant; anti-inflammatory; bilirubin; obesity; overweight; NECROSIS-FACTOR-ALPHA; CONSTITUTIVE ANDROSTANE RECEPTOR; PROLIFERATOR-ACTIVATED RECEPTOR; IMPROVES INSULIN SENSITIVITY; HUMAN FAT-CELLS; ADIPOSE-TISSUE; OXIDATIVE STRESS; METABOLIC SYNDROME; HEME OXYGENASE; CHRONIC INFLAMMATION;

D O I：

10.3390/antiox10091352

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Obesity is a chronic condition involving low-grade inflammation and increased oxidative stress; thus, obese and overweight people have lower values of serum bilirubin. Essentially, bilirubin is a potent endogenous antioxidant molecule with anti-inflammatory, immunomodulatory, antithrombotic, and endocrine properties. This review paper presents the interplay between obesity-related pathological processes and bilirubin, with a focus on adipose tissue and adipokines. We discuss potential strategies to mildly increase serum bilirubin levels in obese patients as an adjunctive therapeutic approach.

引用

页数：16

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