Monogenic immune disorders and severe atopic disease

被引：8
作者：
Biggs, Catherine M. [1 ,2 ]
Lu, Henry Y. [1 ,2 ]
Turvey, Stuart E. [1 ]
机构：
[1] Univ British Columbia, Dept Pediat, British Columbia Childrens Hosp, Vancouver, BC, Canada
[2] Univ British Columbia, Dept Expt Med, Fac Med, Vancouver, BC, Canada
来源：
NATURE GENETICS | 2017年 / 49卷 / 08期
关键词：
B-CELL LYMPHOCYTOSIS; 11; CARD11; DEFICIENCY; MUTATIONS; IMMUNODEFICIENCY;
D O I：
10.1038/ng.3925
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Severe allergic disease is common, and few monogenic causes of atopy have been described. A new study that convincingly links severe atopic dermatitis to heterozygous CARD11 mutations with dominant-interfering activity serves as a timely reminder that clinicians should consider the possibility of an underlying monogenic immune disorder when caring for patients suffering from severe allergic disease.
引用
收藏
页码：1162 / 1163
页数：2
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