Using dextromethorphan potentiometric membrane sensor in analysis of dextromethorphan hydrobromide in pharmaceutical formulation and urine; Computational study

Dextromethorphan (DXM) is an antitussive (cough Hyj/UA suppressant) drug found in many cough medicines. Dextromethorphan has also found other uses in medicine, ranging from pain relief to psychoactive applications. In this study, a potentiometric liquid membrane sensor for simple and fast determination of dextromethorphan hydrobromide in pharmaceutical formulation and urine was constructed. For the membrane preparation, DXM-tetraphenylborate complexes were employed as electroactive materials in the membrane. The wide linear range (10(-6)-10(-2) M), low detection limit (1 x 10(-6) M), and fast response time similar to 5 s) characterize the proposed sensors. Validation of the method shows suitability of the sensors for applications in the determination of dextromethorphan hydrobromide in pharmaceutical formulation and urine.