Methicillin-resistant Staphylococcus aureus resistance to non-β-lactam antimicrobials in the United States from 1996 to 2008

被引:20
作者
Bordon, Jose [1 ,5 ]
Master, Ronald N. [2 ]
Clark, Richard B. [2 ]
Duvvuri, Padmaraj [1 ]
Karlowsky, James A. [3 ]
Ayesu, Kwabena [4 ]
Klotchko, Alena [4 ]
Kapoor, Rama [5 ]
Ramirez, Julio [5 ]
机构
[1] Providence Hosp, Infect Dis Sect, Dept Med, Washington, DC 20017 USA
[2] Quest Diagnost Nichols Inst, Dept Microbiol, Chantilly, VA 20151 USA
[3] Univ Manitoba, Fac Med, Dept Med Microbiol & Infect Dis, Winnipeg, MB R3A 1R9, Canada
[4] Orlando Reg Med Ctr Inc, Dept Med, Orlando, FL 32806 USA
[5] Univ Louisville, Sch Med, Div Infect Dis, Louisville, KY 40202 USA
关键词
MRSA; MRSA resistance to non-beta-lactams; INFECTION; EPIDEMIOLOGY; PREVALENCE; CANADA; IMPACT; RISK;
D O I
10.1016/j.diagmicrobio.2010.03.006
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
We report the resistance rates of Staphylococcus aureus to non-beta-lactam antimicrobials from The Surveillance Network Database-USA (Eurofins-Medinet, Chantilly, VA). Specimens studied were from lower respiratory tract, wounds, and blood. Patients were stratified by age group and patient setting. There were 2,053,219 isolates of S. aureus and 973,116 of methicillin-resistant S. aureus (MRSA). The MRSA rate increased until 2004 and then leveled off. MRSA showed decreasing resistance to tetracycline and trimethoprim sulfamethoxazole (TMP-SMX). By age group, the greatest MRSA rate increase was for individuals 17 years and younger. Non-beta-lactam antimicrobials and particularly TMP-SMX should be considered therapeutic options for staphylococcal infections. (C) 2010 Elsevier Inc. All rights reserved.
引用
收藏
页码:395 / 398
页数:4
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