Synthesis of new phosphonated tripod ligands as putative new therapeutic agents in the chelation treatment of metal intoxications

被引：0

作者：

Burgada, R ^{[1
]}

Bailly, T ^{[1
]}

Lecouvey, M ^{[1
]}

Larue, V ^{[1
]}

Leroux, Y ^{[1
]}

机构：

[1] Univ Paris 13, CNRS, ESA 7031, Lab Chim Struct & Spect Biomol, F-93017 Bobigny, France

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2001年 / 2001卷 / 02期

关键词：

tripodal ligands; metal intoxication; P ligands; chelation therapy; actinides;

D O I：

10.1002/1099-0690(200101)2001:2<349::AID-EJOC349>3.0.CO;2-F

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In a quest for new chelation therapy drugs for the treatment of intoxication by actinides, some new phosphonated chelating tripod Ligands have been synthesized. They have been obtained by means of a coupling reaction between a diethylphosphonoalkanoic acid activated with N,N'-disuccinimidyl carbonate (DSC) and a series of polyamines, with subsequent deprotection of the phosphonate groups.

引用

页码：349 / 352

页数：4

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