Chromatin Remodeling in Mammary Gland Differentiation and Breast Tumorigenesis

被引：23

作者：

Huang, Tim H. -M. ^{[1
]}

Esteller, Manel ^{[2
]}

机构：

[1] Ohio State Univ, Human Canc Genet Program, Dept Mol Virol Immunol & Med Genet, Columbus, OH 43220 USA

[2] Bellvitge Biomed Res Inst IDIBELL, Canc Epigenet & Biol Program PEBC, Barcelona, Catalonia, Spain

来源：

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY | 2010年 / 2卷 / 09期

基金：

美国国家卫生研究院;

关键词：

DNA METHYLATION PATTERNS; CPG ISLAND; EPITHELIAL-CELLS; ABERRANT EXPRESSION; ESTROGEN-RECEPTOR; CANCER-CELLS; GENE-EXPRESSION; HISTONE H4; GENOME; WIDE;

D O I：

10.1101/cshperspect.a004515

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

DNA methylation and histone modifications have essential roles in remodeling chromatin structure of genes necessary for multi-lineage differentiation of mammary stem/progenitor cells. The role of this well-defined epigenetic programming is to heritably maintain transcriptional plasticity of these loci over multiple cell divisions in the differentiated progeny. Epigenetic events can be deregulated in progenitor cells chronically exposed to xenoestrogen or inflammatory microenvironment. In addition, epigenetically mediated silencing of genes associated with tumor suppression can take place, resulting in clonal proliferation of undifferentiated or semidifferentiated cells. Alternatively, microRNAs that negatively regulate the expression of their protein-coding targets may become epigenetically repressed, leading to oncogenic expression of these genes. Here we further discuss interactions between DNA methylation and histone modifications that have significant contributions to the differentiation of mammary stem/progenitor cells and to tumor initiation and progression.

引用

页数：16

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[41] Methylation patterns of the E-cadherin 5′ CpG island are unstable and reflect the dynamic, heterogeneous loss of E-cadherin expression during metastatic progression [J].