Genomic single nucleotide polymorphisms in the offspring of gastric cancer patients predispose to spasmolytic polypeptide-expressing metaplasia after H. pylori infection

被引：11

作者：

Tsai, Yu-Ching ^{[1
,2
,4
]}

Hsiao, Wei-Hsin ^{[1
]}

Lin, Sheng-Hsiang ^{[1
]}

Yang, Hsiao-Bai ^{[3
,5
]}

Cheng, Hsiu-Chi ^{[1
,2
]}

Chang, Wei-Lun ^{[1
,2
]}

Lu, Cheng-Chan ^{[3
]}

Sheu, Bor-Shyang ^{[1
,2
]}

机构：

[1] Natl Cheng Kung Univ, Coll Med, Natl Cheng Kung Univ Hosp, Dept Inst Clin Med, Tainan 70101, Taiwan

[2] Natl Cheng Kung Univ Hosp, Dept Internal Med, Tainan 70428, Taiwan

[3] Natl Cheng Kung Univ, Coll Med, Natl Cheng Kung Univ Hosp, Dept Pathol, Tainan 70101, Taiwan

[4] Tainan Hosp, Dept Hlth, Dept Internal Med, Tainan, Taiwan

[5] Ton Yen Gen Hosp, Dept Pathol, Hsinchu, Taiwan

来源：

JOURNAL OF BIOMEDICAL SCIENCE | 2015年 / 22卷

关键词：

Gastric cancer; Cancer relatives; H; pylori; Corpus predominant gastritis index (CGI); Spasmolytic polypeptide-expressing metaplasia (SPEM); Single nucleotide polymorphisms; COX-2; IL-10; Integrin a5b1; Trefoil factor 2; HELICOBACTER-PYLORI; INTESTINAL METAPLASIA; GENE POLYMORPHISMS; RISK; INFLAMMATION; RELATIVES; CAGA; IDENTIFICATION; ERADICATION; PROGRESSION;

D O I：

10.1186/s12929-015-0121-7

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Background: Gastric cancer exhibits familial clustering, and gastric cancer familial relatives (GCF) tend to present with corpus-predominant gastritis and precancerous lesions as SPEM or IM after H. pylori infection. The study determined whether the children of gastric cancer patients (GCA) had genomic single nucleotide polymorphisms (SNPs) predisposed to the gastric precancerous lesions as spasmolytic polypeptide-expressing metaplasia (SPEM) or intestinal metaplasia (IM). Results: There were 389 family relatives of 193 non-cardiac GCA and 173 duodenal ulcer patients (DU), received blood sampling for DNA collection. The differences of the risk alleles of SNPs in the ITGA5, ITGB1, IL-10, COX-2, RUNX3, and TFF2 genes were compared between 195 children of GCA and 143 DU. The children of GCA had higher allele frequencies of ITGA5-1160 T-carrier (P = 0.006, OR[95% CI] = 2.2[1.2-4]), ITGB1-1949 A-carrier (P = 0.047; OR[95% CI] = 2.8[1.4-5.3]), ITGB1 + 31804 C-carrier (P = 0.013; OR[95% CI] = 4.7[1.7-13.0]), IL-10-592 AA (P = 0.014; OR [95% CI] = 2.3[1.4-4.0]) and COX-2-1195 G-carrier (P = 0.019; OR[95% CI] = 1.7[0.9-3.2]) than DU. The combined genotype with ITGA5-1160/ITGB1-1949/ITGB1 + 31804 as T/A/C carriers and COX-2-1195/IL-10-592 as G-carrier/AA was more prevalent in the children of GCA than in DU (P < 1x10(-4)), and predisposed with a 5.3-fold risk of getting SPEM in the H. pylori-infected children of GCA (P = 0.016). Such risk of getting SPEM increased to 112 folds, if combined with RUNX3 + 492/TFF2-308 as A-carrier/CC in this limited study scale (P = 1x10(-4)). Conclusions: The SNPs of ITGA5-1160/ITGB1-1949/ITGB1 + 31804 as T/A/C carriers and COX-2-1195/IL-10-592 as G-carrier/AA, or more specific to combine RUNX3 + 492/TFF2-308 as A-carrier/CC shall be host factor predisposing to gastric cancer during H. pylori infection, and serve as marker to identify high-risk subjects for H. pylori eradication.

引用

页数：12

共 45 条

[1]

[Anonymous], 1994, IARC Monogr Eval Carcinog Risks Hum, V61, P1

[2] Clinical relevance of Helicobacter pylori cagA and vacA gene polymorphisms [J].