Emerging bioanalytical applications of DNA walkers

被引：111

作者：

Mason, Sean D. ^{[1
]}

Tang, Yanan ^{[1
,2
]}

Li, Yongya ^{[1
]}

Xie, Xiaoyu ^{[1
,2
,3
]}

Li, Feng ^{[1
,2
]}

机构：

[1] Brock Univ, Dept Chem, Ctr Biotechnol, 1812 Sir Isaac Brock Way, St Catharines, ON L2S 3A1, Canada

[2] Sichuan Univ, Coll Chem, Analyt & Testing Ctr, Chengdu 610064, Sichuan, Peoples R China

[3] Xi An Jiao Tong Univ, Sch Pharm, Xian 710061, Shanxi, Peoples R China

来源：

TRAC-TRENDS IN ANALYTICAL CHEMISTRY | 2018年 / 107卷

关键词：

Analytical nanoscience; DNA nanotechnology; DNA walker; Biosensors; Signal amplification; Cell imaging; ELECTROCHEMILUMINESCENCE BIOSENSOR; STRAND-DISPLACEMENT; WALKING MACHINE; ENZYME; NANOMACHINE; AMPLIFICATION; HYBRIDIZATION; ASSEMBLIES; SURFACE; PROTEINS;

D O I：

10.1016/j.trac.2018.08.015

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

DNA walkers are a unique class of dynamic DNA devices that move nucleic acid walkers processively along designated one-, two-, or three-dimensional tracks. Because of the unique mechanical motion, dynamic interaction, and capabilities for signal amplification, programmable signal transduction, high directionality, and predictable analytical performance on the basis of Watson-Crick base paring rules, this class of dynamic DNA nanodevice has gained great attention from the analytical community in the recent years. In the review, we will first describe the general design features of DNA walkers and then focus on their bioanalytical applications ranging from nucleic acid sensing, to protein detection and to cellular imaging and analysis. (C) 2018 Elsevier B.V. All rights reserved.

引用

页码：212 / 221

页数：10

共 60 条

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