Microalbuminuria in nondiabetic patients with nonalcoholic fatty liver disease: association with liver fibrosis

被引：82

作者：

Yilmaz, Yusuf ^{[1
]}

Alanhdab, Yesim Ozen ^{[1
]}

Yonal, Oya ^{[1
]}

Kurt, Ramazan ^{[1
]}

Kedrah, Alla Eldeen ^{[1
]}

Celikel, Cigdem Ataizi ^{[2
]}

Ozdogan, Osman ^{[1
]}

Duman, Deniz ^{[1
]}

Imeryuz, Nese ^{[1
]}

Avsar, Erol ^{[1
]}

Kalayci, Cem ^{[1
]}

机构：

[1] Marmara Univ, Sch Med, Dept Gastroenterol, TR-34662 Istanbul, Turkey

[2] Marmara Univ, Sch Med, Dept Pathol, TR-34662 Istanbul, Turkey

来源：

METABOLISM-CLINICAL AND EXPERIMENTAL | 2010年 / 59卷 / 09期

关键词：

CHRONIC KIDNEY-DISEASE; INSULIN-RESISTANCE; PROVISIONAL REPORT; METABOLIC SYNDROME; CONSULTATION; HYPERTENSION;

D O I：

10.1016/j.metabol.2009.12.012

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Recent evidence has suggested an association between microalbuminuria and ultrasound-diagnosed nonalcoholic fatty liver disease (NAFLD) in patients with diabetes and prediabetes However, few data are available on the occurrence of microalbuminuria in nondiabetic subjects with histologically proven NAFLD We thus evaluated the relationships between microalbuminuria and liver histology in a hospital-based sample of 87 adults with biopsy-proven NAFLD from Turkey An albumin excretion rate less than 30 mg/d was considered within the reference range, whereas an albumin excretion rate from 30 to 300 mg/d was considered to indicate microalbuminuria Compared with those without microalbuminuria (n = 73), NAFLD patients with microalbuminuria (n = 14) had significantly higher homeostasis model assessment of insulin resistance values (3 9 +/- 1 3 vs 5 8 +/- 3 7, P < 001) There were no differences in the prevalence of microalbuminuria in patients with definite nonalcoholic steatohepatitis, borderline nonalcoholic steatohepatitis, and simple fatty liver In the entire study cohort, mean fibrosis scores were significantly higher in patients with microalbuminuria than in those without (1 27 +/- 0.26 vs 0 80 +/- 0 11, P < 05) This difference persisted after adjustment for potential confounders These results indicate the presence of a significant association between the seventy of insulin resistance and microalbuminuria in patients with NAFLD In addition, microalbuminuria may identify NAFLD patients with higher fibrosis scores (C) 2010 Elsevier Inc. All rights reserved

引用

页码：1327 / 1330

页数：4

共 21 条

[1]

Alberti KGMM, 1998, DIABETIC MED, V15, P539, DOI 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO

[2]

2-S

[3] Metabolic syndrome and non-alcoholic fatty liver disease [J].

Almeda-Valdes, Paloma ;

Cuevas-Ramos, Daniel ;

Aguilar-Salinas, Carlos Alberto .

ANNALS OF HEPATOLOGY, 2009, 8 :S18-S24

[4] Nonalcoholic fatty liver disease [J].

Brunt, Elizabeth M. ;

Wong, Vincent W. -S. ;

Nobili, Valerio ;

Day, Christopher P. ;

Sookoian, Silvia ;

Maher, Jacquelyn J. ;

Bugianesi, Elisabetta ;

Sirlin, Claude B. ;

Neuschwander-Tetri, BrentA. ;

Rinella, Mary E. .

NATURE REVIEWS DISEASE PRIMERS, 2015, 1

[5]

Balkau B, 1999, DIABETIC MED, V16, P442

[6] Nonalcoholic fatty liver disease predicts chronic kidney disease in nonhypertensive and nondiabetic Korean men [J].

Chang, Yoosoo ;

Ryu, Seungho ;

Sung, Eunju ;

Woo, Hee-Yeon ;

Oh, Eunock ;

Cha, Kyungsoo ;

Jung, Eunmi ;

Kim, Won Sool .

METABOLISM-CLINICAL AND EXPERIMENTAL, 2008, 57 (04) :569-576

[7] The metabolic syndrome and chronic kidney disease in US adults [J].

Chen, J ;

Muntner, P ;

Hamm, LL ;

Jones, DW ;

Batuman, V ;

Fonseca, V ;

Whelton, PK ;

He, J .

ANNALS OF INTERNAL MEDICINE, 2004, 140 (03) :167-174

[8] Angiotensin receptor blockers in the treatment of NASH/NAFLD: Could they be a first-class option? [J].

Georgescu, Eugen Florin .

ADVANCES IN THERAPY, 2008, 25 (11) :1141-1174

[9] Impact of non-alcoholic fatty liver disease on microalbuminuria in patients with prediabetes and diabetes [J].

Hwang, S. T. ;

Cho, Y. K. ;

Yun, J. W. ;

Park, J. H. ;

Kim, H. J. ;

Park, D. I. ;

Sohn, C. I. ;

Jeon, W. K. ;

Kim, B. I. ;

Rhee, E. J. ;

Oh, K. W. ;

Lee, W. Y. ;

Jin, W. .

INTERNAL MEDICINE JOURNAL, 2010, 40 (06) :437-442

[10] Microalbuminuria is strongly associated with NIDDM and hypertension, but not with the insulin resistance syndrome: the Hoorn study [J].

Jager, A ;

Kostense, PJ ;

Nijpels, G ;

Heine, RJ ;

Bouter, LM ;

Stehouwer, CDA .

DIABETOLOGIA, 1998, 41 (06) :694-700

← 1 2 3 →