Anticancer effects of oleuropein

被引：98

作者：

Shamshoum, Hesham ^{[1
]}

Vlavcheski, Filip ^{[1
]}

Tsiani, Evangelia ^{[1
,2
]}

机构：

[1] Brock Univ, Dept Hlth Sci, 1812 Sir Isaac Brock Way, St Catharines, ON L2S 3A1, Canada

[2] Brock Univ, Ctr Bone & Muscle Hlth, St Catharines, ON, Canada

来源：

BIOFACTORS | 2017年 / 43卷 / 04期

关键词：

olive tree; oleuropein; cancer; proliferation; survival; apoptosis; cell signaling; VIRGIN OLIVE OIL; GROWTH-FACTOR RECEPTOR; CELL-CYCLE ARREST; BREAST-CANCER; PHENOLIC-COMPOUNDS; DNA-DAMAGE; ANTIPROLIFERATIVE ACTIVITY; ANTIOXIDANT DEFENSE; COLORECTAL-CANCER; LEAF EXTRACTS;

D O I：

10.1002/biof.1366

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cancer cells exhibit enhanced proliferation rate and a resistance to apoptosis. Epidemiological studies suggest that olive oil intake is associated with a reduced risk of cancer. Olive oil, olives, and olive leaves contain many polyphenols, including oleuropein. Recently, several studies have demonstrated that oleuropein inhibits proliferation and induces apoptosis in different cancer cell lines. In addition, anticancer effects of oleuropein have been seen in animal studies. These effects are associated with oleuropein's ability to modulate gene expression and activity of a variety of different signaling proteins that play a role in proliferation and apoptosis. This article summarizes the existing in vitro and in vivo studies focusing on the anticancer effects of oleuropein and its effects on key signaling molecules. (c) 2017 BioFactors, 43(4):517-528, 2017

引用

页码：517 / 528

页数：12

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