Molecular Genetics in Epstein-Barr Virus-Associated Malignancies

被引：5

作者：

Umakanthan, Srikanth ^{[1
]}

Bukelo, Maryann M. ^{[2
]}

机构：

[1] Univ West Indies, Fac Med Sci, Dept Paraclin Sci, Pathol Unit, Mt Hope, Trinidad Tobago

[2] North Cent Reg Hlth Author, Dept Anat Pathol, Lab Serv, Eric Williams Med Sci Complex, Champs Fleurs, Trinidad Tobago

来源：

LIFE-BASEL | 2021年 / 11卷 / 07期

关键词：

Epstein-Barr virus; genome; pathogenesis; lymphomas; carcinomas; NK/T CELL LYMPHOMA; BURKITT-LYMPHOMA; GASTRIC-CARCINOMA; BREAST-CANCER; TUMOR; EXPRESSION; INFECTION; APOPTOSIS; FEATURES; RECEPTOR;

D O I：

10.3390/life11070593

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Global genomic studies have detected the role of genomic alterations in the pathogenesis of Epstein-Barr virus (EBV)-associated tumors. EBV oncoproteins cause a vital shift of EBV from an infectious virus to an oncogenic form during the latent and lytic phase within the lymphoid B cells and epithelial cells. This epigenetic alteration modulates the virus and host genomes and inactivates and disrupts numerous tumor suppressors and signaling pathways. Genomic profiling has played the main role in identifying EBV cancer pathogenesis and its related targeted therapies. This article reviews the role of genetic changes in EBV-associated lymphomas and carcinomas. This includes the prolific molecular genesis, key diagnostic tools, and target-specific drugs that have been in recent clinical use.

引用

页数：12

共 90 条

[61] Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics [J].

Schmitz, Roland ;

Young, Ryan M. ;

Ceribelli, Michele ;

Jhavar, Sameer ;

Xiao, Wenming ;

Zhang, Meili ;

Wright, George ;

Shaffer, Arthur L. ;

Hodson, Daniel J. ;

Buras, Eric ;

Liu, Xuelu ;

Powell, John ;

Yang, Yandan ;

Xu, Weihong ;

Zhao, Hong ;

Kohlhammer, Holger ;

Rosenwald, Andreas ;

Kluin, Philip ;

Mueller-Hermelink, Hans Konrad ;

Ott, German ;

Gascoyne, Randy D. ;

Connors, Joseph M. ;

Rimsza, Lisa M. ;

Campo, Elias ;

Jaffe, Elaine S. ;

Delabie, Jan ;

Smeland, Erlend B. ;

Ogwang, Martin D. ;

Reynolds, Steven J. ;

Fisher, Richard I. ;

Braziel, Rita M. ;

Tubbs, Raymond R. ;

Cook, James R. ;

Weisenburger, Dennis D. ;

Chan, Wing C. ;

Pittaluga, Stefania ;

Wilson, Wyndham ;

Waldmann, Thomas A. ;

Rowe, Martin ;

Mbulaiteye, Sam M. ;

Rickinson, Alan B. ;

Staudt, Louis M. .

NATURE, 2012, 490 (7418) :116-120

[62] TNFAIP3 (A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B cell lymphoma [J].

Schmitz, Roland ;

Hansmann, Martin-Leo ;

Bohle, Verena ;

Martin-Subero, Jose Ignacio ;

Hartmann, Sylvia ;

Mechtersheimer, Gunhild ;

Klapper, Wolfram ;

Vater, Inga ;

Giefing, Maciej ;

Gesk, Stefan ;

Stanelle, Jens ;

Siebert, Reiner ;

Kueppers, Ralf .

JOURNAL OF EXPERIMENTAL MEDICINE, 2009, 206 (05) :981-989

[63] BCL-XL inhibition by BH3-mimetic drugs induces apoptosis in models of Epstein-Barr virus-associated T/NK-cell lymphoma [J].

Sejic, Nenad ;

George, Lindsay C. ;

Tierney, Rosemary J. ;

Chang, Catherine ;

Kondrashova, Olga ;

MacKinnon, Ruth N. ;

Lan, Ping ;

Bell, Andrew, I ;

Lessene, Guillaume ;

Long, Heather M. ;

Strasser, Andreas ;

Shannon-Lowe, Claire ;

Kelly, Gemma L. .

BLOOD ADVANCES, 2020, 4 (19) :4775-4787

[64] Epstein-Barr virus-associated lymphomas [J].

Shannon-Lowe, Claire ;

Rickinson, Alan B. ;

Bell, Andrew I. .

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2017, 372 (1732)

[65] HLA-B*07, HLA-DRB1*07, HLA-DRB1*12, and HLA-C*03:02 Strongly Associate With BMI: Data From 1.3 Million Healthy Chinese Adults [J].

Shen, Jie ;

Guo, Tingwei ;

Wang, Tao ;

Zhen, Yisong ;

Ma, Xiao ;

Wang, Yuan ;

Zhang, Zhi-Xin ;

Cai, Jian-Ping ;

Mao, Wei ;

Zhu, Fa-Ming ;

Li, Jian-Ping ;

Wang, Zhen-Lei ;

Zhang, De-Mei ;

Liu, Meng-Li ;

Shan, Xiao-Yan ;

Zhang, Bo-Wei ;

Zhu, Chuan-Fu ;

Deng, Zhi-Hui ;

Yu, Wei-Jian ;

Chen, Qiang ;

Li, Guo-Liang ;

Yang, Tao ;

Lu, Shan ;

Pan, Qin-Qin ;

Fan, Su ;

Wang, Xiao-Yan ;

Zhao, Xing ;

Bi, Xin-Yun ;

Qiao, Yan-Hui ;

Su, Pin-Can ;

Lv, Rong ;

Li, Guo-Ying ;

Li, Heng-Cong ;

Pei, Bin ;

Jiao, Li-Xin ;

Shen, Gang ;

Liu, Jie ;

Feng, Zhi-Hui ;

Su, Yu-Ping ;

Xie, Yu-Bin ;

Di, Wen-Ying ;

Wang, Xin-Yu ;

Liu, Xiang ;

Zhang, Xiao-Ping ;

Du, Dan ;

Liu, Qi ;

Han, Ying ;

Chen, Jia-Wei ;

Gu, Min ;

Baier, Leslie J. .

DIABETES, 2018, 67 (05) :861-871

[66] Epstein-Barr Virus Epidemiology, Serology, and Genetic Variability of LMP-1 Oncogene Among Healthy Population: An Update [J].

Smatti, Maria K. ;

Al-Sadeq, Duaa W. ;

Ali, Nadima H. ;

Pintus, Gianfranco ;

Abou-Saleh, Haissam ;

Nasrallah, Gheyath K. .

FRONTIERS IN ONCOLOGY, 2018, 8

[67]

Sohn MJ, 2018, MEDICINE, V97, DOI [10.1097/MD.0000000000012380, 10.1097/md.0000000000012380]

[68]

Stanfield Brent A, 2017, F1000Res, V6, P386, DOI 10.12688/f1000research.10591.1

[69] The Role of EBV-Induced Hypermethylation in Gastric Cancer Tumorigenesis [J].

Stanland, Lyla J. ;

Luftig, Micah A. .

VIRUSES-BASEL, 2020, 12 (11)

[70]

Stone Marvin J, 2005, Proc (Bayl Univ Med Cent), V18, P368

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