Molecular Genetics in Epstein-Barr Virus-Associated Malignancies

被引：5
作者：
Umakanthan, Srikanth [1 ]
Bukelo, Maryann M. [2 ]
机构：
[1] Univ West Indies, Fac Med Sci, Dept Paraclin Sci, Pathol Unit, Mt Hope, Trinidad Tobago
[2] North Cent Reg Hlth Author, Dept Anat Pathol, Lab Serv, Eric Williams Med Sci Complex, Champs Fleurs, Trinidad Tobago
来源：
LIFE-BASEL | 2021年 / 11卷 / 07期
关键词：
Epstein-Barr virus; genome; pathogenesis; lymphomas; carcinomas; NK/T CELL LYMPHOMA; BURKITT-LYMPHOMA; GASTRIC-CARCINOMA; BREAST-CANCER; TUMOR; EXPRESSION; INFECTION; APOPTOSIS; FEATURES; RECEPTOR;
D O I：
10.3390/life11070593
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Global genomic studies have detected the role of genomic alterations in the pathogenesis of Epstein-Barr virus (EBV)-associated tumors. EBV oncoproteins cause a vital shift of EBV from an infectious virus to an oncogenic form during the latent and lytic phase within the lymphoid B cells and epithelial cells. This epigenetic alteration modulates the virus and host genomes and inactivates and disrupts numerous tumor suppressors and signaling pathways. Genomic profiling has played the main role in identifying EBV cancer pathogenesis and its related targeted therapies. This article reviews the role of genetic changes in EBV-associated lymphomas and carcinomas. This includes the prolific molecular genesis, key diagnostic tools, and target-specific drugs that have been in recent clinical use.
引用
收藏
页数：12
相关论文
共 90 条
[31]   Epstein-Barr Virus and Systemic Autoimmune Diseases [J].
Houen, Gunnar ;
Trier, Nicole Hartwig .
FRONTIERS IN IMMUNOLOGY, 2021, 11
[32]   Host genetics of Epstein-Barr virus infection, latency and disease [J].
Houldcroft, Charlotte J. ;
Kellam, Paul .
REVIEWS IN MEDICAL VIROLOGY, 2015, 25 (02) :71-84
[33]   Epstein-Barr Virus Infection of Mammary Epithelial Cells Promotes Malignant Transformation [J].
Hu, Hai ;
Luo, Man-Li ;
Desmedt, Christine ;
Nabavi, Sheida ;
Yadegarynia, Sina ;
Hong, Alex ;
Konstantinopoulos, Panagiotis A. ;
Gabrielson, Edward ;
Hines-Boykin, Rebecca ;
Pihan, German ;
Yuan, Xin ;
Sotirious, Christos ;
Dittmer, Dirk P. ;
Fingeroth, Joyce D. ;
Wulf, Gerburg M. .
EBIOMEDICINE, 2016, 9 :148-160
[34]   Comparative Study of L-Asparaginase-Based LOP Regimen Over CHOP Regimen Before Radiotherapy for Stage IIE Extranodal Nasal Type NK/T Cell Lymphoma: A Study of 2 Centers [J].
Huang, Limin ;
Yuan, Bin ;
Wu, Haixia ;
Chu, Hongliang ;
Liu, Yayun ;
Wu, Shuang ;
Li, Hong ;
Lu, He ;
Chen, Hui .
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2017, 17 (03) :152-158
[35]  
IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2012, IARC monographs on the evaluation of carcinogenic risks to humans, V100B
[36]   Epstein-Barr Virus (EBV)-associated Gastric Carcinoma [J].
Iizasa, Hisashi ;
Nanbo, Asuka ;
Nishikawa, Jun ;
Jinushi, Masahisa ;
Yoshiyama, Hironori .
VIRUSES-BASEL, 2012, 4 (12) :3420-3439
[37]  
Inha S., 2020, STATPEARLS
[38]   Epstein Barr virus nuclear antigen 1 (EBNA-1) peptides recognized by adult multiple sclerosis patient sera induce neurologic symptoms in a murine model [J].
Jog, Neelakshi R. ;
McClain, Micah T. ;
Heinlen, Latisha D. ;
Gross, Timothy ;
Towner, Rheal ;
Guthridge, Joel M. ;
Axtell, Robert C. ;
Pardo, Gabriel ;
Harley, John B. ;
James, Judith A. .
JOURNAL OF AUTOIMMUNITY, 2020, 106
[39]   An update on Burkitt lymphoma: a review of pathogenesis and multimodality imaging assessment of disease presentation, treatment response, and recurrence [J].
Kalisz, Kevin ;
Alessandrino, Francesco ;
Beck, Rose ;
Smith, Daniel ;
Kikano, Elias ;
Ramaiya, Nikhil H. ;
Tirumani, Sree Harsha .
INSIGHTS INTO IMAGING, 2019, 10 (01)
[40]   The lytic cycle of Epstein-Barr virus is associated with decreased expression of cell surface major histocompatibility complex class I and class II molecules [J].
Keating, S ;
Prince, S ;
Jones, M ;
Rowe, M .
JOURNAL OF VIROLOGY, 2002, 76 (16) :8179-8188
123456789