Mast Cells as Effectors in Atherosclerosis

被引：116
作者：
Bot, Ilze [1 ]
Shi, Guo-Ping [2 ,3 ]
Kovanen, Petri T. [4 ]
机构：
[1] Leiden Univ, Div Biopharmaceut, Leiden Acad Ctr Drug Res, NL-2333 CC Leiden, Netherlands
[2] Brigham & Womans Hosp, Dept Med, Boston, MA USA
[3] Harvard Univ, Sch Med, Boston, MA USA
[4] Wihuri Res Inst, SF-00140 Helsinki, Finland
来源：
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY | 2015年 / 35卷 / 02期
基金：
美国国家卫生研究院;
关键词：
atherosclerosis; leukocytes; mast cells; TRYPTASE LEVELS; PROMOTE ATHEROSCLEROSIS; PLAQUE DESTABILIZATION; MYOCARDIAL-INFARCTION; CORONARY PLAQUES; SHOULDER REGION; CHYMASE; ACTIVATION; DENSITY; APOPTOSIS;
D O I：
10.1161/ATVBAHA.114.303570
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The mast cell is a potent immune cell known for its functions in host defense responses and diseases, such as asthma and allergies. In the past years, accumulating evidence established the contribution of the mast cell to cardiovascular diseases as well, in particular, by its effects on atherosclerotic plaque progression and destabilization. Through its release not only of mediators, such as the mast cell-specific proteases chymase and tryptase, but also of growth factors, histamine, and chemokines, activated mast cells can have detrimental effects on its immediate surroundings in the vessel wall. This results in matrix degradation, apoptosis, and enhanced recruitment of inflammatory cells, thereby actively contributing to cardiovascular diseases. In this review, we will discuss the current knowledge on mast cell function in cardiovascular diseases and speculate on potential novel therapeutic strategies to prevent acute cardiovascular syndromes via targeting of mast cells.
引用
收藏
页码：265 / 271
页数：7
相关论文
共 78 条
[1]  
[Anonymous], 1878, THESIS LEIPZIG U
[2]   THE ASSOCIATION OF MAST-CELLS AND ATHEROSCLEROSIS - A MORPHOLOGIC STUDY OF EARLY ATHEROSCLEROTIC LESIONS IN YOUNG-PEOPLE [J].
ATKINSON, JB ;
HARLAN, CW ;
HARLAN, GC ;
VIRMANI, R .
HUMAN PATHOLOGY, 1994, 25 (02) :154-159
[3]   Our perception of the mast cell from Paul Ehrlich to now [J].
Beaven, Michael A. .
EUROPEAN JOURNAL OF IMMUNOLOGY, 2009, 39 (01) :11-25
[4]  
Bot I, 2007, CIRCULATION, V116, P242
[5]   Perivascular mast cells promote atherogenesis and induce plaque destabilization in apolipoprotein E-deficient mice [J].
Bot, Ilze ;
de Jager, Saskia C. A. ;
Zernecke, Alma ;
Lindstedt, Ken A. ;
van Berkel, Theo J. C. ;
Weber, Christian ;
Biessen, Erik A. L. .
CIRCULATION, 2007, 115 (19) :2516-2525
[6]   Mast cell chymase inhibition reduces atherosclerotic plaque progression and improves plaque stability in ApoE-/- mice [J].
Bot, Ilze ;
Bot, Martine ;
van Heiningen, Sandra H. ;
van Santbrink, Peter J. ;
Lankhuizen, Inge M. ;
Hartman, Peter ;
Gruener, Sabine ;
Hilpert, Hans ;
van Berkel, Theo J. C. ;
Fingerle, Juergen ;
Biessen, Erik A. L. .
CARDIOVASCULAR RESEARCH, 2011, 89 (01) :244-252
[7]   The Neuropeptide Substance P Mediates Adventitial Mast Cell Activation and Induces Intraplaque Hemorrhage in Advanced Atherosclerosis [J].
Bot, Ilze ;
de Jager, Saskia C. A. ;
Bot, Martine ;
van Heiningen, Sandra H. ;
de Groot, Paul ;
Veldhuizen, Roel W. ;
van Berkel, Theo J. C. ;
von der Thusen, Jan H. ;
Biessen, Erik A. L. .
CIRCULATION RESEARCH, 2010, 106 (01) :89-U145
[8]  
Bot I, 2008, CIRCULATION, V118, pS450
[9]   Lysophosphatidic acid triggers mast cell-driven atherosclerotic plaque destabilization by increasing vascular inflammation [J].
Bot, Martine ;
de Jager, Saskia C. A. ;
MacAleese, Luke ;
Lagraauw, H. Maxime ;
van Berkel, Theo J. C. ;
Quax, Paul H. A. ;
Kuiper, Johan ;
Heeren, Ron M. A. ;
Biessen, Erik A. L. ;
Bot, Ilze .
JOURNAL OF LIPID RESEARCH, 2013, 54 (05) :1265-1274
[10]   Atherosclerotic Lesion Progression Changes Lysophosphatidic Acid Homeostasis to Favor its Accumulation [J].
Bot, Martine ;
Bot, Ilze ;
Lopez-Vales, Ruben ;
van de Lest, Chris N. A. ;
Saulnier-Blache, Jean Sebastien ;
Helms, J. Bernd ;
David, Samuel ;
van Berkel, Theo J. C. ;
Biessen, Erik A. L. .
AMERICAN JOURNAL OF PATHOLOGY, 2010, 176 (06) :3073-3084
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