Collateral Genome Instability by DNA Damage in Mitosis

被引：3
|
作者：
Jelluma, Nannette [1 ,2 ]
Kops, Geert J. P. L. [1 ,2 ,3 ]
机构：
[1] Univ Med Ctr Utrecht, Utrecht, Netherlands
[2] Univ Med Ctr Utrecht, Ctr Mol Med, Utrecht, Netherlands
[3] Univ Med Ctr Utrecht, Canc Genom Netherlands, Utrecht, Netherlands
来源：
CANCER DISCOVERY | 2014年 / 4卷 / 11期
关键词：
CHROMOSOMAL INSTABILITY; CANCER; ERRORS; CELLS;
D O I：
10.1158/2159-8290.CD-14-1097
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Chromosome segregation errors and DNA damage are in a vicious cycle in cancer cells. Bakhoum and colleagues show that the molecular response to damaged DNA during mitosis impairs the chromosome segregation machinery, adding a new level to the already dangerous relations between different kinds of genomic instability. (C) 2014 AACR.
引用
收藏
页码：1256 / 1258
页数：3
相关论文
共 50 条
  • [41] Mitosis, double strand break repair, and telomeres: A view from the end How telomeres and the DNA damage response cooperate during mitosis to maintain genome stability
    Cesare, Anthony J.
    BIOESSAYS, 2014, 36 (11) : 1054 - 1061
  • [42] DNA DAMAGE RESPONSE: Mitosis: don't 'repair' the telomere!
    Zlotorynski, Eytan
    NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2014, 15 (05) : 300 - 300
  • [43] Genomic Instability in Fanconi Anemia Results from a Combination of Chromosome Mis-Segregation in Mitosis and Unresolved Interphase DNA Damage
    Cerabona, Donna
    Sater, Zahi Abdul
    Enzor, Rikki
    Nalepa, Grzegorz
    BLOOD, 2014, 124 (21)
  • [44] Plumbagin triggers DNA damage response, telomere dysfunction and genome instability of human breast cancer cells
    Sameni, Safoura
    Hande, M. Prakash
    BIOMEDICINE & PHARMACOTHERAPY, 2016, 82 : 256 - 268
  • [45] Loss of ATRX, Genome Instability, and an Altered DNA Damage Response Are Hallmarks of the Alternative Lengthening of Telomeres Pathway
    Lovejoy, Courtney A.
    Li, Wendi
    Reisenweber, Steven
    Thongthip, Supawat
    Bruno, Joanne
    de Lange, Titia
    De, Saurav
    Petrini, John H. J.
    Sung, Patricia A.
    Jasin, Maria
    Rosenbluh, Joseph
    Zwang, Yaara
    Weir, Barbara A.
    Hatton, Charlie
    Ivanova, Elena
    Macconaill, Laura
    Hanna, Megan
    Hahn, William C.
    Lue, Neal F.
    Reddel, Roger R.
    Jiao, Yuchen
    Kinzler, Kenneth
    Vogelstein, Bert
    Papadopoulos, Nickolas
    Meeker, Alan K.
    PLOS GENETICS, 2012, 8 (07):
  • [46] Higher-Density Culture in Human Embryonic Stem Cells Results in DNA Damage and Genome Instability
    Jacobs, Kurt
    Zambelli, Filippo
    Mertzanidou, Afroditi
    Smolders, Ilse
    Geens, Mieke
    Ha Thi Nguyen
    Barbe, Lise
    Sermon, Karen
    Spits, Claudia
    STEM CELL REPORTS, 2016, 6 (03): : 330 - 341
  • [47] Identification of different classes of genome instability suppressor genes through analysis of DNA damage response markers
    Li, Bin-Zhong
    Kolodner, Richard D.
    Putnam, Christopher D.
    G3-GENES GENOMES GENETICS, 2024, 14 (06):
  • [48] The G2 checkpoint activated by DNA damage does not prevent genome instability in plant cells
    Carballo, Jesus A.
    Pincheira, Juana
    De la Torre, Consuelo
    BIOLOGICAL RESEARCH, 2006, 39 (02) : 331 - 340
  • [49] Flap endonuclease overexpression drives genome instability and DNA damage hypersensitivity in a PCNA-dependent manner
    Becker, Jordan R.
    Gallo, David
    Leung, Wendy
    Croissant, Taylor
    Thu, Yee Mon
    Hai Dang Nguyen
    Starr, Timothy K.
    Brown, Grant W.
    Bielinsky, Anja-Katrin
    NUCLEIC ACIDS RESEARCH, 2018, 46 (11) : 5634 - 5650
  • [50] Collateral damage: benchmarking off-target effects in genome editing
    Dana Carroll
    Genome Biology, 20
12345