Collateral Genome Instability by DNA Damage in Mitosis

被引：3
|
作者：
Jelluma, Nannette [1 ,2 ]
Kops, Geert J. P. L. [1 ,2 ,3 ]
机构：
[1] Univ Med Ctr Utrecht, Utrecht, Netherlands
[2] Univ Med Ctr Utrecht, Ctr Mol Med, Utrecht, Netherlands
[3] Univ Med Ctr Utrecht, Canc Genom Netherlands, Utrecht, Netherlands
来源：
CANCER DISCOVERY | 2014年 / 4卷 / 11期
关键词：
CHROMOSOMAL INSTABILITY; CANCER; ERRORS; CELLS;
D O I：
10.1158/2159-8290.CD-14-1097
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Chromosome segregation errors and DNA damage are in a vicious cycle in cancer cells. Bakhoum and colleagues show that the molecular response to damaged DNA during mitosis impairs the chromosome segregation machinery, adding a new level to the already dangerous relations between different kinds of genomic instability. (C) 2014 AACR.
引用
收藏
页码：1256 / 1258
页数：3
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