Structure-activity relationships for the analgesic activity of gallic acid derivatives

被引：31

作者：

Krogh, R

Yunes, RA

Andricopulo, AD

机构：

[1] Univ Michigan, Coll Pharm, Ann Arbor, MI 48109 USA

[2] Univ Fed Santa Catarina, Dept Chem, BR-88090 Florianopolis, SC, Brazil

来源：

FARMACO | 2000年 / 55卷 / 11-12期

关键词：

analgesic activity; gallic acid; structure-activity relationships; QSAR models;

D O I：

10.1016/S0014-827X(00)00094-X

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Values of ID50 for a collection of structurally-related gallic acid derivatives have been employed to create a predictive quantitative structure-activity relationship (QSAR) which links structure to values of analgesic activity. The QSAR model developed has substantial predictive power for the design of novel gallic acid derivatives having improved analgesic potency. (C) 2000 Elsevier Science S.A. All rights reserved.

引用

页码：730 / 735

页数：6

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