Abnormal Amygdala Resting-State Functional Connectivity in Irritable Bowel Syndrome

被引：46

作者：

Qi, R. ^{[1
]}

Liu, C. ^{[2
]}

Ke, J. ^{[1
]}

Xu, Q. ^{[1
]}

Ye, Y. ^{[2
]}

Jia, L. ^{[3
]}

Wang, F. ^{[2
]}

Zhang, L. J. ^{[1
]}

Lu, G. M. ^{[1
]}

机构：

[1] Nanjing Univ, Sch Med, Jinling Hosp, Dept Med Imaging, 305 Zhongshan East Rd, Nanjing 210002, Jiangsu, Peoples R China

[2] Nanjing Univ, Sch Med, Jinling Hosp, Dept Gastroenterol, Nanjing 210002, Jiangsu, Peoples R China

[3] Nanjing Univ, Sch Med, Jinling Hosp, Dept Emergency Med, Nanjing 210002, Jiangsu, Peoples R China

来源：

AMERICAN JOURNAL OF NEURORADIOLOGY | 2016年 / 37卷 / 06期

关键词：

BRAIN RESPONSES; GI DISORDERS; PAIN; NETWORKS; STIMULI; FMRI; NEUROSCIENCE; VALIDATION; MECHANISMS; DEPRESSION;

D O I：

10.3174/ajnr.A4655

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

BACKGROUND AND PURPOSE: Functional neuroimaging studies in irritable bowel syndrome have revealed abnormalities in the corticolimbic regions, specifically, hyperactivity of the amygdala during visceral and somatic stimulation. This study investigated changes in the neural circuitry of the amygdala in patients with irritable bowel syndrome based on resting-state functional connectivity. MATERIALS AND METHODS: Functional MR imaging data were acquired from 31 patients with irritable bowel syndrome and 32 healthy controls (matched for age, sex, and educational level) during rest, and the resting-state functional connectivity of bilateral amygdalae was compared. Multiple regression was performed to investigate the relationship between clinical indices of patients with irritable bowel syndrome and resting-state functional connectivity. RESULTS: Compared with healthy controls, patients with irritable bowel syndrome had higher positive resting-state functional connectivity between the amygdala and insula, midbrain, parahippocampal gyrus, pre- and postcentral gyri, and supplementary motor area. The inclusion of anxiety and depression as covariates did not alter amygdala resting-state functional connectivity differences between the study groups. Multiple covariate regression results showed that the pain intensity in patients with irritable bowel syndrome positively correlated with resting-state functional connectivity between the amygdala and supplementary motor area, pre- and postcentral gyri, and insula, while the Irritable Bowel Syndrome Symptom Severity Score positively correlated with resting-state functional connectivity between the amygdala and insula and midbrain. CONCLUSIONS: Patients with irritable bowel syndrome showed disturbed amygdala resting-state functional connectivity with the corticolimbic regions, which could partly account for the enhanced emotional arousal and visceral information processing associated with irritable bowel syndrome.

引用

页码：1139 / 1145

页数：7

共 54 条

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