The Protective Effect of Adrenomedullin on Renal Injury, in a Model of Abdominal Aorta Cross-Clamping

被引：17

作者：

Oyar, Eser Oz ^{[1
]}

Kiris, Ilker ^{[2
]}

Gulmen, Senol ^{[2
]}

Ceyhan, Betul Mermi ^{[3
]}

Cure, Medine Cumhur ^{[3
]}

Delibas, Namik ^{[3
]}

Lortlar, Nese ^{[4
]}

Okutan, Huseyin ^{[2
]}

机构：

[1] Gazi Univ, Fac Med, Dept Physiol, Ankara, Turkey

[2] Suleyman Demirel Univ, Fac Med, Dept Cardiovasc Surg, TR-32200 Isparta, Turkey

[3] Suleyman Demirel Univ, Fac Med, Dept Biochem, TR-32200 Isparta, Turkey

[4] Gazi Univ, Fac Med, Dept Med Histol & Embryol, Ankara, Turkey

来源：

THORACIC AND CARDIOVASCULAR SURGEON | 2012年 / 60卷 / 01期

关键词：

adrenomedullin; renal injury; infrarenal abdominal aorta; ischemia-reperfusion; ISCHEMIA/REPERFUSION INJURY; NITRIC-OXIDE; SURGERY; REPERFUSION; SYSTEM; KIDNEY; RATS; APOPTOSIS; ISCHEMIA; PEPTIDE;

D O I：

10.1055/s-0031-1293607

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Renal injury induced by aortic ischemia-reperfusion (IR) is an important factor in the development of postoperative acute renal failure following abdominal aortic surgery. The aim of this study was to examine the effect of adrenomedullin (AM) on kidney injury induced by infrarenal abdominal aortic IR in rats. Thirty-two Wistar Albino rats were randomized into four groups (eight per group) as follows: Control group, IR group (120-minute ischemia and 120-minute reperfusion), IR + AM group (a bolus intravenously of 0.05 mu g/kg/min AM), and control + AM group. At the end of the experiment, blood and kidney tissue specimens were obtained for biochemical analysis. Immunohistological evaluation of the rat kidney tissues was also done. IR significantly increased (p < 0.05 vs control group) and AM significantly decreased (p < 0.05 vs. IR group) all of the biochemical parameters. Immunohistological evaluation showed that AM attenuated morphological changes as apoptosis associated with kidney injury. The results of this study indicate that AM attenuates both biochemically and immunohistopathologically kidney injury induced by aortic IR in rats.

引用

页码：5 / 10

页数：6

共 29 条

[1] Patients with poor preoperative ejection fraction have a higher plasma response of adrenomedullin in response to open heart surgery [J].