The three human monocyte subsets: implications for health and disease

被引：532

作者：

Wong, Kok Loon ^{[1
]}

Yeap, Wei Hseun ^{[1
]}

Tai, June Jing Yi ^{[1
]}

Ong, Siew Min ^{[1
]}

Truong Minh Dang ^{[1
]}

Wong, Siew Cheng ^{[1
]}

机构：

[1] ASTAR, Singapore Immunol Network SIgN, Singapore 138648, Singapore

来源：

IMMUNOLOGIC RESEARCH | 2012年 / 53卷 / 1-3期

关键词：

Monocyte subsets; CD14; CD16; Inflammation; Classical subset; Intermediate subset; Non-classical subset; INFLAMMATORY-BOWEL-DISEASE; NECROSIS-FACTOR-ALPHA; HEPATITIS-C VIRUS; HUMAN PERIPHERAL-BLOOD; HUMAN DENDRITIC CELLS; TOLL-LIKE RECEPTOR-2; PROINFLAMMATORY CD14(+)CD16(+)DR(++) MONOCYTES; MYCOBACTERIUM-TUBERCULOSIS INFECTION; ANGIOTENSIN-CONVERTING ENZYME; AMYLOID PRECURSOR PROTEIN;

D O I：

10.1007/s12026-012-8297-3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Human blood monocytes are heterogeneous and conventionally subdivided into two subsets based on CD16 expression. Recently, the official nomenclature subdivides monocytes into three subsets, the additional subset arising from the segregation of the CD16+ monocytes into two based on relative expression of CD14. Recent whole genome analysis reveal that specialized functions and phenotypes can be attributed to these newly defined monocyte subsets. In this review, we discuss these recent results, and also the description and utility of this new segregation in several disease conditions. We also discuss alternative markers for segregating the monocyte subsets, for example using Tie-2 and slan, which do not necessarily follow the official method of segregating monocyte subsets based on relative CD14 and CD16 expressions.

引用

页码：41 / 57

页数：17

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