Split-spectrum amplitude-decorrelation angiography with optical coherence tomography

被引：1507

作者：

Jia, Yali ^{[1
]}

Tan, Ou ^{[1
]}

Tokayer, Jason ^{[2
]}

Potsaid, Benjamin ^{[3
,4
]}

Wang, Yimin ^{[1
]}

Liu, Jonathan J. ^{[3
]}

Kraus, Martin F. ^{[3
,5
]}

Subhash, Hrebesh ^{[1
]}

Fujimoto, James G. ^{[3
]}

Hornegger, Joachim ^{[5
]}

Huang, David ^{[1
]}

机构：

[1] Oregon Hlth & Sci Univ, Casey Eye Inst, Portland, OR 97239 USA

[2] Univ So Calif, Dept Elect Engn, Los Angeles, CA 90089 USA

[3] MIT, Dept Elect Engn & Comp Sci, Cambridge, MA 02139 USA

[4] Thorlabs Inc, Adv Imaging Grp, Newton, NJ 07860 USA

[5] Univ Erlangen Nurnberg, Pattern Recognit Lab, D-91058 Erlangen, Germany

来源：

OPTICS EXPRESS | 2012年 / 20卷 / 04期

关键词：

RETINAL BLOOD-FLOW; SWEPT-SOURCE; VASCULAR PERFUSION; VELOCITY; CIRCULATION; MOTION; EYE; MICROCIRCULATION; CAPILLARIES; PERFORMANCE;

D O I：

10.1364/OE.20.004710

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

Amplitude decorrelation measurement is sensitive to transverse flow and immune to phase noise in comparison to Doppler and other phase-based approaches. However, the high axial resolution of OCT makes it very sensitive to the pulsatile bulk motion noise in the axial direction. To overcome this limitation, we developed split-spectrum amplitude-decorrelation angiography (SSADA) to improve the signal-to-noise ratio (SNR) of flow detection. The full OCT spectrum was split into several narrower bands. Inter-B-scan decorrelation was computed using the spectral bands separately and then averaged. The SSADA algorithm was tested on in vivo images of the human macula and optic nerve head. It significantly improved both SNR for flow detection and connectivity of microvascular network when compared to other amplitude-decorrelation algorithms. (C) 2012 Optical Society of America

引用

页码：4710 / 4725

页数：16

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