Staphylococcus aureus-Derived Extracellular Vesicles Enhance the Efficacy of Endocrine Therapy in Breast Cancer Cells

被引：23
作者：
An, Jeongshin [1 ,2 ]
Kwon, Hyungju [1 ]
Lim, Woosung [1 ]
Moon, Byung-In [1 ]
机构：
[1] Ewha Womans Univ, Mokdong Hosp, Sch Med, Dept Surg, 1071 Anyangcheon Ro, Seoul 07985, South Korea
[2] Ewha Womans Univ, Mokdong Hosp, Sch Med, Inst Convergence Med Res, 1071 Anyangcheon Ro, Seoul 07985, South Korea
来源：
JOURNAL OF CLINICAL MEDICINE | 2022年 / 11卷 / 07期
基金：
新加坡国家研究基金会;
关键词：
breast cancer; microbiome; bacterial extracellular vesicle; Staphylococcus; MICROBIOME; INHIBITION; EXPRESSION; TAMOXIFEN; ESTROGEN;
D O I：
10.3390/jcm11072030
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The microbiome involved in the human estrogen metabolism is known as the estrobolome. This study aimed to show that the estrobolome can be used in breast cancer treatment. We first analyzed the blood microbiome composition of healthy controls and patients with breast cancer. In particular, we investigated the bacteria producing beta-glucuronidase and/or beta-galactosidase, which are involved in estrogen metabolism in the human body. Staphylococcus species were more abundant in healthy controls than in breast cancer patients and therefore were selected for further analyses. The effect of Staphylococcus aureus on endocrine therapy was analyzed by a combination treatment with tamoxifen. Analysis of the microbiome of blood samples showed that species producing beta-glucuronidase were more abundant in breast cancer patients than in healthy controls. Further experiments confirmed that the efficacy of tamoxifen increased when administered in conjugation with the extracellular vesicles (EVs) of S. aureus. Based on our results, we deduced that S. aureus EVs could potentially be used as adjuvants for breast cancer treatment in the future.
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页数：13
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