Multiple Sclerosis and Autoimmune Comorbidities

被引：21

作者：

Nociti, Viviana ^{[1
,2
]}

Romozzi, Marina ^{[1
]}

机构：

[1] Fdn Policlin Univ Agostino Gemelli IRCCS, Ctr Sderosi Multipla, I-00168 Rome, Italy

[2] Univ Cattolica Sacro Cuore, I-00168 Rome, Italy

来源：

JOURNAL OF PERSONALIZED MEDICINE | 2022年 / 12卷 / 11期

关键词：

multiple sclerosis; personalized medicine; autoimmune; comorbidities; CORTICAL SPREADING DEPRESSION; TYPE-1; DIABETES-MELLITUS; RHEUMATOID-ARTHRITIS; ULCERATIVE-COLITIS; EPILEPTIC SEIZURES; THYROID-DISEASE; BRAIN-STEM; PREVALENCE; RISK; DISABILITY;

D O I：

10.3390/jpm12111828

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

Multiple sclerosis (MS) is a chronic inflammatory and neurodegenerative disease of the central nervous system characterized by broad inter- and intraindividual heterogeneity and different prognoses. Multisystem comorbidities are frequent features in people with MS (PwMS) and can affect treatment choices, quality of life, disability and mortality. In this scenario, autoimmune comorbidities play a cardinal role for several reasons, such as the implication on MS pathogenesis, diagnostic delay, disease activity, disability progression, brain atrophy, and treatment choice. However, the impact of an autoimmune comorbid condition on MS is not fully elucidated. This review aims to summarize the currently available data on the incidence and prevalence of autoimmune diseases in PwMS, the possible effect of this association on clinical and neuroradiological MS course and its impact on treatment choice.

引用

页数：12

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