Mitochondria as target of Quantum dots toxicity

被引：65
|
作者：
Li, Jiahan [1 ,2 ]
Zhang, Yue [1 ,2 ]
Xiao, Qi [1 ,2 ]
Tian, Fangfang [1 ,2 ]
Liu, Xiaorong [1 ,2 ]
Li, Ran [1 ,2 ]
Zhao, Guangyuan [1 ,2 ]
Jiang, Fenglei [1 ,2 ]
Liu, Yi [1 ,2 ]
机构：
[1] Wuhan Univ, Coll Chem & Mol Sci, Minist Educ, State Key Lab Virol, Wuhan 430072, Peoples R China
[2] Wuhan Univ, Coll Chem & Mol Sci, Minist Educ, Key Lab Analyt Chem Biol & Med, Wuhan 430072, Peoples R China
来源：
JOURNAL OF HAZARDOUS MATERIALS | 2011年 / 194卷
基金：
中国国家自然科学基金;
关键词：
Mitochondria; Quantum dots; Mitochondrial permeability transition; Apoptosis; PERMEABILITY TRANSITION; LIPID-PEROXIDATION;
D O I：
10.1016/j.jhazmat.2011.07.113
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
Quantum dots (QDs) hold great promise in many biological applications, with the persistence of safety concerns about the environment and human health. The present work investigated the potential toxicity of CdTe QDs on the function of mitochondria isolated from rat livers by examining mitochondrial respiration, swelling, and lipid peroxidation. We observed that QDs can significantly affect the mitochondrial membrane properties, bioenergetics and induce mitochondrial permeability transition (MPT). These results will help us learn more about QDs toxicity at subcellular (mitochondrial) level. (C) 2011 Elsevier B.V. All rights reserved.
引用
收藏
页码：440 / 444
页数：5
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