IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction

被引：2090

作者：

Kawai, T

Takahashi, K

Sato, S

Coban, C

Kumar, H

Kato, H

Ishii, KJ

Takeuchi, O

Akira, S

机构：

[1] Osaka Univ, Dept Host Def, Microbial Dis Res Inst, Suita, Osaka 5650871, Japan

[2] Osaka Univ, Microbial Dis Res Inst, Combined Program Microbiol & Immunol, 21st Century COE, Suita, Osaka 5650871, Japan

[3] Kyoto Univ, Grad Sch Med, Dept Gastroenterol & Hepatol, Sakyo Ku, Kyoto 6068507, Japan

来源：

NATURE IMMUNOLOGY | 2005年 / 6卷 / 10期

关键词：

D O I：

10.1038/ni1243

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Type I interferons are central mediators for antiviral responses. Using high-throughput functional screening of interferon inducers, we have identified here a molecule we call interferon-beta promoter stimulator 1 (IPS-1). Overexpression of IPS-1 induced type I interferon and interferon-inducible genes through activation of IRF3, IRF7 and NF-kappa B transcription factors. TBK1 and IKKi protein kinases were required for the IPS-1-mediated interferon induction. IPS-1 contained an N-terminal CARD-like structure that mediated interaction with the CARD of RIG-I and Mda5, which are cytoplasmic RNA helicases that sense viral infection. 'Knockdown' of IPS-1 by small interfering RNA blocked interferon induction by virus infection. Thus, IPS-1 is an adaptor involved in RIG-I-and Mda5-mediated antiviral immune responses.

引用

收藏

页码：981 / 988

页数：8

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