Asthma and Three Colinear Comorbidities: Obesity, OSA, and GERD

被引：62

作者：

Althoff, Meghan D. ^{[1
]}

Ghincea, Alexander ^{[2
]}

Wood, Lisa G. ^{[3
]}

Holguin, Fernando ^{[1
]}

Sharma, Sunita ^{[1
]}

机构：

[1] Univ Colorado Anschutz Sch Med, Dept Med, Div Pulm Sci & Crit Care Med, Aurora, CO USA

[2] Yale Sch Med, Pulm Crit Care & Sleep Med, New Haven, CT USA

[3] Univ Newcastle, Prior Res Ctr Hlth Lungs, Hunter Med Res Inst, Sch Biomed Sci & Pharm,Fac Hlth & Med, Callaghan, NSW, Australia

来源：

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE | 2021年 / 9卷 / 11期

关键词：

Asthma; Obesity; Obstructive sleep apnea; Gastroesophageal reflux disease; OBSTRUCTIVE SLEEP-APNEA; GASTROESOPHAGEAL-REFLUX DISEASE; BODY-MASS INDEX; POSITIVE AIRWAY PRESSURE; QUALITY-OF-LIFE; ASYMMETRIC DIMETHYLARGININE; PULMONARY-FUNCTION; WEIGHT-LOSS; CLINICAL-OUTCOMES; CLUSTER-ANALYSIS;

D O I：

10.1016/j.jaip.2021.09.003

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Asthma is a complex disease with heterogeneous phenotypes and endotypes that are incompletely understood. Obesity, obstructive sleep apnea, and gastroesophageal reflux disease cooccur in patients with asthma at higher rates than in those without asthma. Although these diseases share risk factors, there are some data suggesting that these comorbidities have shared inflammatory pathways, drive the development of asthma, or worsen asthma control. This review discusses the epidemiology, pathophysiology, management recommendations, and key knowledge gaps of these common comorbidities. Crown Copyright (C) 2021 Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology

引用

页码：3877 / 3884

页数：8

共 121 条

[21] Prevalence of Gastroesophageal Reflux Disease and Proton Pump Inhibitor-Refractory Symptoms [J].

Delshad, Sean D. ;

Almario, Christopher V. ;

Chey, William D. ;

Spiegel, Brennan M. R. .

GASTROENTEROLOGY, 2020, 158 (05) :1250-+

[22] Inflammatory and Comorbid Features of Patients with Severe Asthma and Frequent Exacerbations [J].

Denlinger, Loren C. ;

Phillips, Brenda R. ;

Ramratnam, Sinna ;

Ross, Kristie ;

Bhakta, Nirav R. ;

Cardet, Juan Carlos ;

Castro, Mario ;

Peters, Stephen P. ;

Phipatanakul, Wanda ;

Aujle, Shean ;

Bacharier, Leonard B. ;

Bleecker, Eugene R. ;

Comhair, Suzy A. A. ;

Coverstone, Andrea ;

DeBoer, Mark ;

Erzurum, Serpil C. ;

Fain, Sean B. ;

Fajt, Merritt ;

Fitzpatrick, Anne M. ;

Gaffin, Jonathan ;

Gaston, Benjamin ;

Hastie, Annette T. ;

Hawkins, Gregory A. ;

Holguin, Fernando ;

Irani, Anne-Marie ;

Israel, Elliot ;

Levy, Bruce D. ;

Ngoc Ly ;

Meyers, Deborah A. ;

Moore, Wendy C. ;

Myers, Ross ;

Opina, Maria Theresa D. ;

Peters, Michael C. ;

Schiebler, Mark L. ;

Sorkness, Ronald L. ;

Teague, W. Gerald ;

Wenzel, Sally E. ;

Woodruff, Prescott G. ;

Mauger, David T. ;

Fahy, John V. ;

Jarjour, Nizar N. .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2017, 195 (03) :302-313

[23] Improvement in co-morbidities following weight loss from gastric bypass surgery [J].

Dhabuwala, A ;

Cannan, RJ ;

Stubbs, RS .

OBESITY SURGERY, 2000, 10 (05) :428-435

[24] Effect of obesity on clinical presentation and response to treatment in asthma [J].

Dixon, Anne E. ;

Shade, David M. ;

Cohen, Rubin I. ;

Skloot, Gwen S. ;

Holbrook, Janet T. ;

Smith, Lewis J. ;

Lima, John J. ;

Allayee, Hooman ;

Irvin, Charles G. ;

Wise, Robert A. .

JOURNAL OF ASTHMA, 2006, 43 (07) :553-558

[25] Effects of Obstructive Sleep Apnea and Gastroesophageal Reflux Disease on Asthma Control in Obesity [J].

Dixon, Anne E. ;

Clerisme-Beaty, Emmanuelle M. ;

Sugar, Elizabeth A. ;

Cohen, Rubin I. ;

Lang, Jason E. ;

Brown, Ellen D. ;

Richter, Joel E. ;

Irvin, Charles G. ;

Mastronarde, John G. .

JOURNAL OF ASTHMA, 2011, 48 (07) :707-713

[26] Marked improvement in asthma after Lap-Band®:: Surgery for morbid obesity [J].

Dixon, JB ;

Chapman, L ;

O'Brien, P .

OBESITY SURGERY, 1999, 9 (04) :385-389

[27] Hypoxia suppresses symptom perception in asthma [J].

Eckert, DJ ;

Catcheside, PG ;

Smith, JH ;

Frith, PA ;

McEvoy, RD .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2004, 169 (11) :1224-1230

[28] Obesity is an independent risk factor for GERD symptoms and erosive esophagitis [J].

El-Serag, HB ;

Graham, DY ;

Satia, JA ;

Rabeneck, L .

AMERICAN JOURNAL OF GASTROENTEROLOGY, 2005, 100 (06) :1243-1250

[29] The relationship of serum triglycerides, serum HDL, and obesity to the risk of wheezing in 85,555 adults [J].

Fenger, R. V. ;

Gonzalez-Quintela, A. ;

Linneberg, A. ;

Husemoen, L. L. N. ;

Thuesen, B. H. ;

Aadahl, M. ;

Vidal, C. ;

Skaaby, T. ;

Sainz, J. C. ;

Calvo, E. .

RESPIRATORY MEDICINE, 2013, 107 (06) :816-824

[30] Asthma Exacerbations in Patients with Type 2 Diabetes and Asthma on Glucagon-like Peptide-1 Receptor Agonists [J].

Foer, Dinah ;

Beeler, Patrick E. ;

Cui, Jing ;

Karlson, Elizabeth W. ;

Bates, David W. ;

Cahill, Katherine N. .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2021, 203 (07) :831-840

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