Asthma and Three Colinear Comorbidities: Obesity, OSA, and GERD

被引：62

作者：

Althoff, Meghan D. ^{[1
]}

Ghincea, Alexander ^{[2
]}

Wood, Lisa G. ^{[3
]}

Holguin, Fernando ^{[1
]}

Sharma, Sunita ^{[1
]}

机构：

[1] Univ Colorado Anschutz Sch Med, Dept Med, Div Pulm Sci & Crit Care Med, Aurora, CO USA

[2] Yale Sch Med, Pulm Crit Care & Sleep Med, New Haven, CT USA

[3] Univ Newcastle, Prior Res Ctr Hlth Lungs, Hunter Med Res Inst, Sch Biomed Sci & Pharm,Fac Hlth & Med, Callaghan, NSW, Australia

来源：

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE | 2021年 / 9卷 / 11期

关键词：

Asthma; Obesity; Obstructive sleep apnea; Gastroesophageal reflux disease; OBSTRUCTIVE SLEEP-APNEA; GASTROESOPHAGEAL-REFLUX DISEASE; BODY-MASS INDEX; POSITIVE AIRWAY PRESSURE; QUALITY-OF-LIFE; ASYMMETRIC DIMETHYLARGININE; PULMONARY-FUNCTION; WEIGHT-LOSS; CLINICAL-OUTCOMES; CLUSTER-ANALYSIS;

D O I：

10.1016/j.jaip.2021.09.003

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Asthma is a complex disease with heterogeneous phenotypes and endotypes that are incompletely understood. Obesity, obstructive sleep apnea, and gastroesophageal reflux disease cooccur in patients with asthma at higher rates than in those without asthma. Although these diseases share risk factors, there are some data suggesting that these comorbidities have shared inflammatory pathways, drive the development of asthma, or worsen asthma control. This review discusses the epidemiology, pathophysiology, management recommendations, and key knowledge gaps of these common comorbidities. Crown Copyright (C) 2021 Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology

引用

页码：3877 / 3884

页数：8

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