The suppressive effect of mangiferin with exercise on blood lipids in type 2 diabetes

被引:59
作者
Miura, T
Iwamoto, N
Kato, M
Ichiki, H
Kubo, M
Komatsu, Y
Ishida, T
Okada, M
Tanigawa, K
机构
[1] Suzuka Univ Med Sci, Dept Clin Nutr, Suzuka, Mie 5100293, Japan
[2] Suzuka Univ Med Sci, Hitech Res Ctr, Suzuka, Mie 5100293, Japan
[3] Tsumura & Co, Tsumura Cent Res Labs, Ibaraki, Osaka 3001100, Japan
关键词
mangiferin; hypolipidemic effect; type; 2; diabetes;
D O I
10.1248/bpb.24.1091
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The effect of mangiferin (MF) with exercise on bood lipids was studied in KK-AY mice, an animal model of type 2 diabetes. MF (30 mg/kg) reduced the blood cholesterol (p <0.05) and triglyceride level (p <0.01) of KK-A(y) mice with exercise 2 weeks after oral administration when compared with the control group. Diabetes also often has elevated lipid levels. Therefore, it may be that MF has beneficial effects on hyperlipidemia in type 2 diabetes.
引用
收藏
页码:1091 / 1092
页数:2
相关论文
共 9 条
[1]  
FUJITA M, 1982, CHEM PHARM BULL, V30, P2342
[2]   SKELETAL-MUSCLE PLASMA-MEMBRANE GLUCOSE-TRANSPORT AND GLUCOSE TRANSPORTERS AFTER EXERCISE [J].
GOODYEAR, LJ ;
HIRSHMAN, MF ;
KING, PA ;
HORTON, ED ;
THOMPSON, CM ;
HORTON, ES .
JOURNAL OF APPLIED PHYSIOLOGY, 1990, 68 (01) :193-198
[3]  
Ichiki H, 1998, BIOL PHARM BULL, V21, P1389, DOI 10.1248/bpb.21.1389
[4]   Effect of mangiferin with exercise in early stage symptom of type 2 diabetic mice [J].
Iwamoto, N ;
Miura, T ;
Kato, M ;
Takemoto, T ;
Ichiki, H ;
Kubo, M ;
Komatsu, Y ;
Isihara, E ;
Sasaki, H ;
Ishida, T ;
Seino, Y ;
Tanigawa, K .
BIOMEDICAL RESEARCH-TOKYO, 2000, 21 (04) :221-223
[5]   A DIABETIC STRAIN OF MOUSE [J].
NAKAMURA, M .
PROCEEDINGS OF THE JAPAN ACADEMY, 1962, 38 (07) :348-&
[6]  
Nishimura M., 1969, EXP ANIMALS, V18, P147, DOI [DOI 10.1538/EXPANIM1957.18.4_147, 10.1538/expanim1957.18.4_147]
[7]  
RECHMOND W, 1978, CLIN CHEM, V24, P1343
[8]  
SAITO S, 1994, CHEM PHARM BULL, V42, P2342, DOI 10.1248/cpb.42.2342
[9]  
SPAYD RW, 1978, CLIN CHEM, V24, P1343