Breast cancer stem cells programs: enter the (non)-code

被引：4

作者：

Salvador, Marion A. ^{[1
]}

Birnbaum, Daniel ^{[1
]}

Charafe-Jauffret, Emmanuelle ^{[2
,3
,4
]}

Ginestier, Christophe ^{[5
]}

机构：

[1] Canc Res Ctr Marseille, Mol Oncol Lab, Marseille, France

[2] Aix Marseille Univ, Breast Pathol, Marseille, France

[3] Mol Oncol Lab, Marseille, France

[4] Breast Canc Stem Cells Grp, Marseille, France

[5] Mol Oncol Lab, Breast Canc Stem Cells Grp, Marseille, France

来源：

BRIEFINGS IN FUNCTIONAL GENOMICS | 2016年 / 15卷 / 03期

关键词：

cancer stem cell; breast cancer epigenetics; noncoding; RNA; long; RNA microRNA; TO-MESENCHYMAL TRANSITION; INVASION-METASTASIS CASCADE; LONG NONCODING RNAS; TAMOXIFEN RESISTANCE; MIR-200; FAMILY; SELF-RENEWAL; IN-VIVO; MICRORNA SIGNATURES; SIGNALING PATHWAY; TUMOR-SUPPRESSOR;

D O I：

10.1093/bfgp/elw003

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Breast tumors exhibit a hierarchical cellular organization driven by several subpopulations of cancer stem cells (CSCs). These breast CSC subpopulations are able to infinitely self-renew and to differentiate, giving rise to tumor heterogeneity. Accumulating evidence show that breast CSCs resist conventional therapies and initiate tumor relapse. The development of anti-CSCs therapies may therefore greatly improve patient survival. A better elucidation of molecular circuitries involved in stemness would offer new relevant targets. Noncoding RNAs, especially microRNAs and long noncoding RNAs, are regulators of cell identity and are notably found deregulated in breast CSCs. This review will focus on noncoding RNAs involved in CSCs biology during breast cancer initiation, maintenance, therapeutic resistance and metastatic progression. Potential clinical applications using noncoding RNAs as biomarkers or therapies will be discussed.

引用

页码：186 / 199

页数：14

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