Treatment of implanted liver tumors with focused ultrasound

被引:27
作者
Chen, LL
Ter Haar, G
Hill, CR
Eccles, SA
Box, G
机构
[1] Inst Canc Res, Joint Dept Phys, Sutton, Surrey, England
[2] Royal Marsden Hosp, Sutton, Surrey, England
基金
英国医学研究理事会;
关键词
ultrasound surgery; tissue ablation; liver tumors; HSN fibrosarcoma; histologic changes; tissue culture; cell survival; local tumor control;
D O I
10.1016/S0301-5629(98)00134-3
中图分类号
O42 [声学];
学科分类号
070206 ; 082403 ;
摘要
This article reports treatment of implanted liver tumors (HSN fibrosarcoma) with focused ultrasound (FUS). Experiments were carried out on implanted liver tumors in vivo. In order to determine the optimum treatment conditions, various combinations of exposure parameters were investigated. The results showed that it is possible to achieve total destruction of tumor cells in the treatment volume using an FUS system with a frequency of 1.7 MHz, with in situ I-SAL of 261 W/cm(2), 5-8 exposure duration, and 1.5-mm exposure separation, with an in situ I-SAL of 266 W/cm(2), 10-s duration, and 2-mm separation, or with ill situ I-SAL of 213 W/cm(2), 8-s duration, and 1.5-mm separation. Fifteen selected tumors were treated with these experimentally determined "optimum" exposure conditions. All the tumors were destroyed completely. Assessment of tumor viability in the treated volume was performed using both histologic and tissue culture methods. The mechanism of tumor damage, the limitations of the tumor model, and the effect of exposure parameters and liver blood flow on the treatment are discussed. (C) 1998 World Federation for Ultrasound in Medicine & Biology.
引用
收藏
页码:1475 / 1488
页数:14
相关论文
共 38 条
[1]  
[Anonymous], 1976, IEEE ULTRASONICS S P, V44, P44
[2]   EFFECT OF BLOOD PERFUSION ON THE ABLATION OF LIVER PARENCHYMA WITH HIGH-INTENSITY FOCUSED ULTRASOUND [J].
CHEN, L ;
TERHAAR, G ;
HILL, CR ;
DWORKIN, M ;
CARNOCHAN, P ;
YOUNG, H ;
BENSTED, JPM .
PHYSICS IN MEDICINE AND BIOLOGY, 1993, 38 (11) :1661-1673
[3]  
Chen L, 1993, THESIS U LONDON
[4]   Influence of ablated tissue on the formation of high-intensity focused ultrasound lesions [J].
Chen, LL ;
terHaar, G ;
Hill, CR .
ULTRASOUND IN MEDICINE AND BIOLOGY, 1997, 23 (06) :921-931
[5]   HISTOLOGICAL-CHANGES IN RAT-LIVER TUMORS TREATED WITH HIGH-INTENSITY FOCUSED ULTRASOUND [J].
CHEN, LL ;
RIVENS, I ;
TERHAAR, G ;
RIDDLER, S ;
HILL, CR ;
BENSTED, JPM .
ULTRASOUND IN MEDICINE AND BIOLOGY, 1993, 19 (01) :67-74
[6]   Temperature rise recorded during lesion formation by high-intensity focused ultrasound [J].
Clarke, RL ;
terHaar, GR .
ULTRASOUND IN MEDICINE AND BIOLOGY, 1997, 23 (02) :299-306
[7]   FOCUSED US SYSTEM FOR MR IMAGING-GUIDED TUMOR ABLATION [J].
CLINE, HE ;
HYNYNEN, K ;
WATKINS, RD ;
ADAMS, WJ ;
SCHENCK, JF ;
ETTINGER, RH ;
FREUND, WR ;
VETRO, JP ;
JOLESZ, FA .
RADIOLOGY, 1995, 194 (03) :731-737
[8]   MAGNETIC RESONANCE-GUIDED THERMAL SURGERY [J].
CLINE, HE ;
SCHENCK, JF ;
WATKINS, RD ;
HYNYNEN, K ;
JOLESZ, FA .
MAGNETIC RESONANCE IN MEDICINE, 1993, 30 (01) :98-106
[9]   MR TEMPERATURE MAPPING OF FOCUSED ULTRASOUND SURGERY [J].
CLINE, HE ;
HYNYNEN, K ;
HARDY, CJ ;
WATKINS, RD ;
SCHENCK, JF ;
JOLESZ, FA .
MAGNETIC RESONANCE IN MEDICINE, 1994, 31 (06) :628-636
[10]  
FRY F J, 1978, Ultrasound in Medicine and Biology, V4, P337, DOI 10.1016/0301-5629(78)90022-4