Direct, pyrrolidine sulfonamide promoted enantioselective aldol reactions of α,α-dialkyl aldehydes:: synthesis of quaternary carbon-containing β-hydroxy carbonyl compounds

被引：80
作者：
Wang, W
Li, H
Wang, J
机构：
[1] Univ New Mexico, Dept Chem, Albuquerque, NM 87131 USA
[2] E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China
来源：
TETRAHEDRON LETTERS | 2005年 / 46卷 / 30期
关键词：
aldehyde; aldol reaction; asymmetric catalysis; organocatalyst; pyrrolidine sulfonamide;
D O I：
10.1016/j.tetlet.2005.05.067
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A procedure has been developed for direct, asymmetric aldol reactions of alpha,alpha-dialkyl aldehydes with aromatic aldehydes, which produces quaternary carbon-containing beta-hydroxy carbonyl compounds. The processes, promoted by the organocatalyst (S) pyrrolidine sulfonamide, take place in high yields with exceptionally high levels of enantioselectivities. (c) 2005 Elsevier Ltd. All rights reserved.
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页码：5077 / 5079
页数：3
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