Mitochondrial stress signaling: a pathway unfolds

被引:49
作者
Broadley, Sarah A. [1 ]
Hartl, F. Ulrich [1 ]
机构
[1] Max Planck Inst Biochem, Dept Cellular Biochem, D-82152 Martinsried, Germany
关键词
D O I
10.1016/j.tcb.2007.11.003
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Disruption of protein homeostasis in mitochondria elicits a cellular response, which upregulates mitochondrial chaperones and other factors that serve to remodel the mitochondrial-folding environment. In a recent study, Haynes and colleagues uncovered a novel signal transduction pathway underlying this process. The upstream mitochondrial component of this pathway is an orthologue of Escherichia coli CIpP, which functions in the bacterial heat-shock response. These findings suggest that molecular aspects of stress sensing might be conserved between bacteria and mitochondria.
引用
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页码:1 / 4
页数:4
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