Cytotoxic bafilomycin analogues 6/5/5 with tricyclic ring system from a marine-derived Streptomyces sp

被引:9
|
作者
Li, Jia-Qi [1 ]
Zhao, Hao-Wen [1 ]
Ma, Zhong-Jun [1 ]
机构
[1] Zhejiang Univ, Ocean Coll, Inst Marine Biol & Pharmacol, Zhoushan 316021, Peoples R China
基金
中国国家自然科学基金;
关键词
Bafilomycins; 6/5/5 tricyclic ring; Marine Streptomyces; Cytotoxicity; MACROLIDES;
D O I
10.1016/j.tetlet.2020.151874
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Two bafilomycin derivatives with an unprecedented 6/5/5 tricyclic ring system (1 and 2), along with five known analogues (3-7), were identified from a marine Streptomyces sp. The structures of 1 and 2 were elucidated by analysis of HRESIMS, extensive NMR spectroscopic methods, GLAD DET C-13 NMR calculations and comparison of the spectroscopic data with those of known related compounds. Compound 2 exhibited significant cytotoxicity against PC3 human prostate carcinoma cells with IC50 value of 4.99 +/- 0.15 mu M. (C) 2020 Elsevier Ltd. All rights reserved.
引用
收藏
页数:3
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