GPR61methylation in cord blood: a potential target of prenatal exposure to air pollutants

被引:2
|
作者
Feng, Feifei [1 ]
Huang, Li [1 ]
Zhou, Guoyu [2 ]
Wang, Jia [2 ]
Zhang, Ruiqin [3 ]
Li, Zhiyuan [1 ]
Zhang, Yawei [4 ,5 ]
Ba, Yue [2 ]
机构
[1] Zhengzhou Univ, Dept Toxicol, Sch Publ Hlth, Zhengzhou, Peoples R China
[2] Zhengzhou Univ, Dept Environm Hlth, Sch Publ Hlth, 100 Kexue Ave, Zhengzhou 450001, Henan, Peoples R China
[3] Zhengzhou Univ, Coll Chem & Mol Engn, Zhengzhou, Peoples R China
[4] Yale Sch Med, Dept Surg, New Haven, CT USA
[5] Yale Sch Publ Hlth, Dept Environm Hlth Sci, New Haven, CT USA
基金
中国国家自然科学基金;
关键词
DNA methylation; GPR61promoter region; air pollution; newborns; LOW-BIRTH-WEIGHT; DNA METHYLATION; POLLUTION; INSULIN; GROWTH; GPR61;
D O I
10.1080/09603123.2020.1773414
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
To explore the impact of air pollutants exposure during pregnancy on infant DNA methylation, we identified correlated methylated genes in maternal and cord blood samples using the Illumina Human Methylation 27 k BeadChip. Quantitative methylation-specific PCR (QMS-PCR) was performed to validate the target gene methylation pattern in 568 participants. Then the association between air pollutants exposure and DNA methylation level in the target gene was investigated. TheGPR61gene with a higher methylation level both in mothers and newborns was identified as the target gene, and we found a positive mother-infant DNA methylation correlation in the promoter region ofGPR61. Air pollutants exposure during entire pregnancy was associated with maternal and infantGPR61DNA methylation. After adjusting confounding variables, maternal air pollutants exposure was still associated with infantGPR61DNA methylation. In summary,GPR61methylation in cord blood may be a potential target of prenatal exposure to air pollutants.
引用
收藏
页码:463 / 472
页数:10
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