Opuntia humifusa modulates morphological changes characteristic of asthma via IL-4 and IL-13 in an asthma murine model

被引:14
|
作者
Lee, Soon-Young [1 ]
Bae, Chun-Sik [2 ]
Choi, Young-Hoon [3 ]
Seo, Nam-Sook [1 ]
Na, Chang-Su [1 ]
Yoo, Jin-Cheol [4 ]
Cho, Seung Sik [3 ]
Park, Dae-Hun [1 ]
机构
[1] Dongshin Univ, Coll Oriental Med, Naju 58245, Jeonnam, South Korea
[2] Chonnam Natl Univ, Coll Vet Med, Gwangju, South Korea
[3] Mokpo Natl Univ, Coll Pharm, Dept Pharm, Muan 58554, Jeonnam, South Korea
[4] Chosun Univ, Coll Pharm, Dept Pharm, Gwangju, South Korea
关键词
Opuntia humifusa; ovalbumin-induced asthma; IL-4; IL-13; TNF-ALPHA; AIRWAYS HYPERREACTIVITY; ALLERGIC DISEASES; CELL; SUPPLEMENTATION; INTERLEUKIN-4; INFLAMMATION; EOSINOPHILIA; NEUTROPHILS; EXPRESSION;
D O I
10.1080/16546628.2017.1393307
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
Asthma is a chronic pulmonary disease that affects an estimated 235 million people worldwide, but asthma drugs have many adverse effects. Opuntia humifusa (eastern prickly pear) has been used as a food and traditional medicine worldwide; however, its anti-asthmatic effects have not been reported. We evaluated O. humifusa as a potential therapeutic or preventive component of antiasthmatic drugs. We divided ovalbumin-sensitized mice into the following groups: normal control, asthma-induced control, dexamethasone-treated group (positive control), 50 mg/kg O. humifusa-treated group, 100 mg/kg O. humifusa-treated group, and 500 mg/kg O. humifusa-treated group. Levels of Th1/Th2/Th17-related cytokines were evaluated using RT-PCR, ELISA, and immunohistochemistry. O. humifusa dose-dependently suppressed the morphological changes typically observed in asthma, such as goblet cell hyperplasia, inflammatory cell infiltration, mucous hypersecretion, and relative basement membrane thickening in the respiratory system. These results may be attributable to regulation of Th1-/Th2-/Th17-related factors, especially interleukin (IL)-4 and IL-13. We conclude that O. humifusa is a potential anti-asthmatic functional food.
引用
收藏
页数:11
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