Catalytic enantioselective direct Michael additions of ketones to alkylidene malonates

被引：266

作者：

Betancort, JM

Sakthivel, K

Thayumanavan, R

Barbas, CF

机构：

[1] Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

[2] Scripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 27期

基金：

美国国家卫生研究院;

关键词：

asymmetric catalyst; asymmetric synthesis; Michael reaction;

D O I：

10.1016/S0040-4039(01)00793-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Enantioselective direct Michael additions of ketones using (S)-1-(2-pyrroldinylmethyl)-pyrrolidine as a catalyst are described. Michael adducts with up to 91% e.e. were obtained by the reaction of alkylidene malonates with simple unactivated ketones under mild reaction conditions. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：4441 / 4444

页数：4

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