One-pot synthesis of α-alkylated nitriles with carbonyl compounds through consecutive aldol reaction/hydrogenation using a hydrotalcite-supported palladium nanoparticle as a multifunctional heterogeneous catalyst

被引：54
作者：
Motokura, K [1 ]
Fujita, N [1 ]
Mori, K [1 ]
Mizugaki, T [1 ]
Ebitani, K [1 ]
Kaneda, K [1 ]
机构：
[1] Osaka Univ, Grad Sch Engn Sci, Dept Mat Engn Sci, Toyonaka, Osaka 5608531, Japan
来源：
TETRAHEDRON LETTERS | 2005年 / 46卷 / 33期
基金：
日本学术振兴会;
关键词：
alpha-alkylation of nitrile; aldol reaction; hydrogenation; one-pot synthesis; palladium; hydrotalcite; heterogeneous catalyst;
D O I：
10.1016/j.tetlet.2005.06.053
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
alpha-Alkylation of various nitriles with carbonyl compounds successfully proceeded using a hydrotalcite-supported palladium nanoparticle as a multifunctional catalyst. The alkylated nitriles were formed through aldol reaction at base sites on the hydrotalcite surface followed by hydrogenation by molecular hydrogen on the palladium nanoparticle. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5507 / 5510
页数：4
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