The new unsaturated acyclic C-5 pyrimidine nucleoside analogues: Synthesis, cytostatic and anti-HIV evaluations

被引：0

作者：

Gazivoda, Tatjana ^{[1
]}

Raic-Malic, Silvana ^{[1
]}

Kraljevic-Pavelic, Sandra

Pavelic, Kresimir

Balzarini, Jan

Mintas, Mladen ^{[1
]}

机构：

[1] Univ Zagreb, Fac Chem Engn & Technol, Dept Organ Chem, Zagreb 10000, Croatia

来源：

CHEMISTRY OF NUCLEIC ACID COMPONENTS | 2008年 / 10卷

关键词：

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of the novel C-5 alkynyl pyrimidine nucleoside analogues (1-14) in which the sugar moiety was replaced by the conformationally restricted (Z)- and (E)-2-butenyl spacer between the phthalimido and pyrimidine ring were synthesized by using Sonogashira cross-coupling reaction. Cytostatic activity evaluation of the novel compounds showed that E-isomers (8-14) exhibited better cytostatic activities than the corresponding Z-isomers (1-7). The compounds 3, 4 and 14 expressed some marginal inhibitory activity against HIV-1 and HIV-2.

引用

页码：439 / 441

页数：3

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