Biocompatible Red Fluorescent Organic Nanoparticles with Tunable Size and Aggregation-Induced Emission for Evaluation of Blood-Brain Barrier Damage

被引：85

作者：

Cai, Xiaolei ^{[1
,2
]}

Bandla, Aishwarya ^{[3
,4
]}

Mao, Duo ^{[1
]}

Feng, Guangxue ^{[1
]}

Qin, Wei ^{[5
,6
]}

Liao, Lun-De ^{[3
,7
]}

Thakor, Nitish ^{[3
,4
]}

Tang, Ben Zhong ^{[5
,6
]}

Liu, Bin ^{[1
,8
]}

机构：

[1] Natl Univ Singapore, Dept Chem & Biomol Engn, 4 Engn Dr 4, Singapore 117585, Singapore

[2] Natl Univ Singapore, NUS Grad Sch Integrat Sci & Engn, 28 Med Dr,05-01, Singapore 117456, Singapore

[3] Natl Univ Singapore, Singapore Inst Neurotechnol SINAPSE, 28 Med Dr, Singapore 117456, Singapore

[4] Natl Univ Singapore, Dept Biomed Engn, 21 Lower Kent Ridge Rd, Singapore 119077, Singapore

[5] Hong Kong Univ Sci & Technol, Dept Chem, Kowloon 999077, Hong Kong, Peoples R China

[6] Hong Kong Univ Sci & Technol, Div Biomed Engn, Kowloon 999077, Hong Kong, Peoples R China

[7] Natl Hlth Res Inst, Inst Biomed Engn & Nanomed, 35 Keyan Rd, Zhunan Town 35053, Miaoli County, Taiwan

[8] Inst Mat Res & Engn, 2 Fusionopolis Way,Innovis 08-03, Singapore 138634, Singapore

来源：

ADVANCED MATERIALS | 2016年 / 28卷 / 39期

基金：

新加坡国家研究基金会;

关键词：

LIGHT-UP BIOPROBE; CEREBRAL-ISCHEMIA; EVANS BLUE; IN-VITRO; PERMEABILITY; DOTS; PROTEINS; PHOTOTHROMBOSIS; DISRUPTION; MODULATION;

D O I：

10.1002/adma.201601191

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Detection of damage to the blood-brain barrier (BBB) is important for the diagnosis of brain diseases and therapeutic drug evaluation. The widely used probe, Evans blue, suffers from low specificity and high toxicity in vivo. It is shown that organic nanoparticles with tuneable size, good biocompatibility, and aggregation-induced emission characteristics offer high detection specificity to detect BBB damage via a photothrombotic ischemia rat model.

引用

页码：8760 / 8765

页数：6

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