Two new sesquiterpene lactones from the supercritical fluid extract of Centipeda minima

被引：22

作者：

Wu, Peng ^{[1
,2
]}

Li, Xiao-Guang ^{[3
]}

Liang, Ning ^{[1
,2
]}

Wang, Guo-Cai ^{[1
,2
]}

Ye, Wen-Cai ^{[1
,2
]}

Zhou, Guang-Xiong ^{[1
,2
]}

Li, Yao-Lan ^{[1
,2
]}

机构：

[1] Jinan Univ, Inst Tradit Chinese Med & Nat Prod, Guangzhou 510632, Guangdong, Peoples R China

[2] Jinan Univ, Guangdong Prov Key Lab Pharmacodynam Constituents, Guangzhou 510632, Guangdong, Peoples R China

[3] Jinan Univ, Joint Lab Brain Funct & Hlth, Guangzhou 510632, Guangdong, Peoples R China

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2012年 / 14卷 / 06期

基金：

中国国家自然科学基金;

关键词：

Centipeda minima; sesquiterpene lactones; supercritical fluid extract; antiproliferative activity; CNE CELLS; APOPTOSIS;

D O I：

10.1080/10286020.2012.670222

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new sesquiterpene lactones, minimolides G (1) and H (2), were isolated from the supercritical fluid extract of Centipeda minima. Their structures were elucidated on the basis of extensive analyses of spectroscopic data including IR, HR-ESI-MS, 1D and 2D NMR. Compounds 1 and 2 displayed inhibitory activity against human nasopharyngeal cancer cell line (CNE) with IC50 values of 61.4 and 28.7 mu M, respectively.

引用

页码：515 / 520

页数：6

共 8 条

[1] Two new terpene glucosides and antitumor agents from Centipeda minima [J].

Ding, Lin-Fen ;

Liu, Ying ;

Liang, Heng-Xing ;

Liu, Da-Peng ;

Zhou, Guang-Biao ;

Cheng, Yong-Xian .

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2009, 11 (08) :732-736

[2] 6-O-Angeloylenolin induces apoptosis through a mitochondrial/caspase and NF-κB pathway in human leukemia HL60 cells [J].

Li ChangLong ;

Wu HeZhen ;

Huang YongPing ;

Yang YanFang ;

Liu YanWen ;

Liu JianWen .

BIOMEDICINE & PHARMACOTHERAPY, 2008, 62 (06) :401-409

[3]

Lin R., 2005, PHARMACOPOEIA CHINA, P241

[4]

Shi Z., 1983, Flora of China, P132

[5]

Su MX, 2010, NAT PROD COMMUN, V5, P151

[6] 2β-(Isobutyryloxy)florilenalin, a Sesquiterpene Lactone Isolated from the Medicinal Plant Centipeda minima, Induces Apoptosis in Human Nasopharyngeal Carcinoma CNE Cells [J].

Su, Miaoxian ;

Li, Yaolan ;

Chung, Hau Yin ;

Ye, Wencai .

MOLECULES, 2009, 14 (06) :2135-2146

[7] Supercritical fluid extraction assisted isolation of sesquiterpene lactones with antiproliferative effects from Centipeda minima [J].

Wu, Peng ;

Su, Mia-Xian ;

Wang, Ying ;

Wang, Guo-Cai ;

Ye, Wen-Cai ;

Chung, Hau-Yin ;

Li, Juan ;

Jiang, Ren-Wang ;

Li, Yao-Lan .

PHYTOCHEMISTRY, 2012, 76 :133-140

[8]

Xu R.S., 1997, NATURAL PRODUCT CHEM, P223

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