Regulation of cytoplasmic mRNA decay

被引:510
作者
Schoenberg, Daniel R. [1 ,2 ]
Maquat, Lynne E. [3 ,4 ]
机构
[1] Ohio State Univ, Dept Mol & Cellular Biochem, Columbus, OH 43210 USA
[2] Ohio State Univ, Ctr RNA Biol, Columbus, OH 43210 USA
[3] Univ Rochester, Dept Biochem & Biophys, Rochester, NY 14642 USA
[4] Univ Rochester, Ctr RNA Biol, Rochester, NY 14642 USA
关键词
ACTIVATED PROTEIN-KINASE; AU-RICH ELEMENT; EXON-JUNCTION COMPLEX; GENE-EXPRESSION; HUMAN-CELLS; POSTTRANSLATIONAL MODIFICATION; POSTTRANSCRIPTIONAL REGULATION; DEPENDENT PHOSPHORYLATION; ENDONUCLEOLYTIC CLEAVAGE; TRANSLATIONAL REPRESSION;
D O I
10.1038/nrg3160
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Discoveries made over the past 20 years highlight the importance of mRNA decay as a means of modulating gene expression and thereby protein production. Up until recently, studies largely focused on identifying cis-acting sequences that serve as mRNA stability or instability elements, the proteins that bind these elements, how the process of translation influences mRNA decay and the ribonucleases that catalyse decay. Now, current studies have begun to elucidate how the decay process is regulated. This Review examines our current understanding of how mammalian cell mRNA decay is controlled by different signalling pathways and lays out a framework for future research.
引用
收藏
页码:246 / 259
页数:14
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