Metabolic control of immune tolerance in health and autoimmunity

被引：38
作者：
Carbone, Fortunata [1 ]
La Rocca, Claudia [1 ]
De Candia, Paola [2 ]
Procaccini, Claudio [1 ]
Colamatteo, Alessandra [3 ]
Micillo, Teresa [3 ]
De Rosa, Veronica [1 ,3 ]
Matarese, Giuseppe [1 ,4 ]
机构：
[1] CNR, IEOS, Lab Immunol, I-80131 Naples, Italy
[2] IRCCS MultiMed, I-20138 Milan, Italy
[3] Fdn Santa Lucia, Unita Neurolmmunol, I-00143 Rome, Italy
[4] Univ Napoli Federico II, Dipartimento Med Mol & Biotecnol Med, Via Pansini 5, I-80131 Naples, Italy
来源：
SEMINARS IN IMMUNOLOGY | 2016年 / 28卷 / 05期
关键词：
Metabolism; Immune tolerance; Autoimmune diseases; Obesity; Malnutrition; REGULATORY T-CELLS; BODY-MASS INDEX; PROTEIN-ENERGY MALNUTRITION; COLONY-ENHANCING FACTOR; HUMAN ADIPOSE-TISSUE; SERUM LEPTIN LEVELS; MULTIPLE-SCLEROSIS; RHEUMATOID-ARTHRITIS; GENE-EXPRESSION; ACCELERATOR HYPOTHESIS;
D O I：
10.1016/j.smim.2016.09.006
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The filed that links immunity and metabolism is rapidly expanding. The adipose tissue, by secreting a series of immune regulators called adipokines, represents the common mediator linking metabolic processes and immune system functions. The dysregulation of adipokine secretion, occurring in obese individuals or in conditions of malnutrition or dietary restriction, affects the activity of immune cells resulting in inflammatory autoimmune responses or increased susceptibility to infectious diseases. Alterations of cell metabolism that characterize several autoimmune diseases strongly support the idea that the immune tolerance is also regulated by metabolic pathways. The comprehension of the molecular mechanisms underlying these alterations may lead to the development of novel therapeutic strategies to control immune cell differentiation and function in conditions of autoimmunity. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码：491 / 504
页数：14
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