An scFv phage clone that binds to human β2-microglobulin

被引：2
|
作者：
Jwang, B [1 ]
Yerushalmi, N [1 ]
Kreitman, RJ [1 ]
Engberg, J [1 ]
Pastan, I [1 ]
机构：
[1] NCI, Mol Biol Lab, DBS, Bethesda, MD 20892 USA
来源：
IMMUNOTECHNOLOGY | 1999年 / 4卷 / 3-4期
关键词：
anti-beta(2)-microglobulin antibody; phage display; scFv antibody; single-chain HLA-A2;
D O I：
10.1016/S1380-2933(98)00023-2
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Using phage display technology, a novel mouse scFv phage clone DI was generated from mice immunized with single-chain HLA-A2, the human MHC class I molecules. D1 recognized a determinant in beta(2)-microglobulin. It reacted with beta(2)-microglobulin associated with the heavy chain of HLA-A2, recombinant beta(2)-microglobulin made in Escherichia coli or beta(2)-microglobulin prepared from human urine. The heavy chain variable region of D1 belongs to gene Family VII and the light chain variable region belongs to the kappa chain gene family XI according to the Kabat database. Published by Elsevier Science B.V.
引用
收藏
页码：231 / 236
页数：6
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