Facile synthesis of 3-methyl-4-arylmethylene-isoxazol-5(4H)-ones catalysed by sodium silicate in an aqueous medium

被引：55
作者：
Liu, Qing [1 ]
Wu, Ren-Tao [1 ]
机构：
[1] Taishan Univ, Dept Chem & Environm Sci, Tai An 271021, Shandong, Peoples R China
来源：
JOURNAL OF CHEMICAL RESEARCH | 2011年 / 10期
关键词：
sodium silicate pentahydrate; 3-methyl-4-arylmethylene-isoxazol-5(4H)-ones; one-pot synthesis; aqueous media; ONE-POT SYNTHESIS; MICROWAVE IRRADIATION; CONDENSATION; ALDEHYDES;
D O I：
10.3184/174751911X13176501108975
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Isoxazoles have significant hypoglycaemic, immunosuppressive, anti-inflammatory, and anti-bacterial activities. A convenient high yielding procedure for the one-pot synthesis of 3-methyl-4-arylmethylene-isoxazol-5(4H)-ones by the condensation of ethyl acetoacetate, hydroxylamine hydrochloride and aromatic aldehydes in the presence of sodium silicate pentahydrate as an efficient catalyst in water at room temperature is described.
引用
收藏
页码：598 / 599
页数：2
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