C-C bond activation with selective functionalization: preparation of unsymmetrical biaryls from benzonitriles

被引：131

作者：

Miller, JA ^{[1
]}

机构：

[1] DSM Catalytica Pharmaceut, Mt View, CA 94043 USA

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 40期

关键词：

D O I：

10.1016/S0040-4039(01)01476-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

For the first time. benzonitriles have been shown to participate in metal-catalyzed cross coupling reactions via activation of the C-CN bond. Thus, reaction of a benzonitrile,vith an aryl Grignard derivative in the presence of a Ni catalyst can readily provide the corresponding unsymmetrical biaryl in high yield and with high selectivity. (C), 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：6991 / 6993

页数：3

共 5 条

[1] REPLACEMENT OF BENZIDINE BY COPPER ETHYLACETOACETATE AND TETRA BASE AS SPOT-TEST REAGENT FOR HYDROGEN CYANIDE AND CYANOGEN [J].