Diverse functions of pericytes in cerebral blood flow regulation and ischemia

被引：80

作者：

Fernandez-Klettl, Francisco ^{[1
]}

Priller, Josef ^{[1
,2
,3
]}

机构：

[1] Charite, Dept Neuropsychiat, Lab Mol Psychiat, D-10117 Berlin, Germany

[2] DZNE, Cluster Excellence NeuroCure, Berlin, Germany

[3] BIH, Berlin, Germany

来源：

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM | 2015年 / 35卷 / 06期

关键词：

hemodynamic; neurovascular coupling; pericytes; scar formation; stroke; IN-VIVO; VASCULAR NETWORK; SMOOTH-MUSCLE; BRAIN; CORTEX; SCAR; CAPILLARIES; MICE; TONE;

D O I：

10.1038/jcbfm.2015.60

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Pericytes are mural cells with contractile properties. Here, we provide evidence that microvascular pericytes modulate cerebral blood flow in response to neuronal activity ('functional hyperemia'). Besides their role in neurovascular coupling, pericytes are responsive to brain damage. Cerebral ischemia is associated with constrictions and death of capillary pericytes, followed by fibrotic reorganization of the ischemic tissue.,The data suggest that precapillary arterioles and capillaries are major sites of hemodynamic regulation in the brain.

引用

页码：883 / 887

页数：5

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