Cytotoxic withanolides from Physalis angulata

被引：20
|
作者：
Gao, Caiyun [1 ]
Li, Ruijun [1 ]
Zhou, Miaomiao [1 ]
Yang, Yanwei [1 ]
Kong, Lingyi [1 ]
Luo, Jun [1 ]
机构：
[1] China Pharmaceut Univ, Dept Nat Med Chem, State Key Lab Nat Med, Nanjing, Jiangsu, Peoples R China
来源：
NATURAL PRODUCT RESEARCH | 2018年 / 32卷 / 06期
基金：
中国国家自然科学基金;
关键词：
Withanolides; Physalis angulata L; Cytotoxic activity; FOLK MEDICINE; CONSTITUENTS; PERUVIANA; GLYCOSIDE; MINIMA; PLANTS;
D O I：
10.1080/14786419.2017.1338281
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A new withanolide (1), physagulide P, together with five known withanolides (2-6), was isolated from the aerial parts of Physalis angulata L. The structure of new compound was elucidated on the basis of extensive spectroscopic techniques, including 1D, 2D NMR and HRESIMS. The activity screening indicated that compound 1 showed significant cytotoxicities against the human osteosarcoma cell line MG-63, HepG-2 hepatoma cells and breast cancer cells MDA-MB-231 with the IC50 value of 3.50, 4.22 and 15.74 mu M.
引用
收藏
页码：676 / 681
页数：6
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