Protein Phosphatase 5 Mediates Lipid Metabolism through Reciprocal Control of Glucocorticoid Receptor and Peroxisome Proliferator-activated Receptor-γ (PPARγ)

被引：72

作者：

Hinds, Terry D., Jr. ^{[1
,2
]}

Stechschulte, Lance A. ^{[1
,2
]}

Cash, Harrison A. ^{[1
,2
]}

Whisler, Donald ^{[1
,2
]}

Banerjee, Ananya ^{[1
,2
]}

Yong, Weidong ^{[3
]}

Khuder, Saja S. ^{[1
,2
]}

Kaw, Meenakshi K. ^{[1
,2
]}

Shou, Weinian ^{[3
]}

Najjar, Sonia M. ^{[1
,2
]}

Sanchez, Edwin R. ^{[1
,2
]}

机构：

[1] Univ Toledo, Coll Med, Ctr Diabet & Endocrine Res, Toledo, OH 43614 USA

[2] Univ Toledo, Coll Med, Dept Physiol & Pharmacol, Toledo, OH 43614 USA

[3] Indiana Univ Sch Med, Dept Pediat, Herman B Wells Ctr Pediat Res, Pediat Cardiol Sect, Indianapolis, IN 46202 USA

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2011年 / 286卷 / 50期

基金：

美国国家卫生研究院;

关键词：

TETRATRICOPEPTIDE REPEAT DOMAIN; HEAT-SHOCK-PROTEIN; ADIPOCYTE DIFFERENTIATION; TRANSCRIPTIONAL ACTIVITY; ADIPOSE-TISSUE; SERINE/THREONINE PHOSPHATASE; IMMUNOPHILIN FKBP51; STEROID-RECEPTORS; SQUIRREL-MONKEY; MESSENGER-RNA;

D O I：

10.1074/jbc.M111.311662

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Background: The glucocorticoid (GR) and peroxisome proliferator-activated (PPAR gamma) receptors are antagonists of lipid metabolism. Results: Protein phosphatase 5 (PP5) dephosphorylates GR and PPAR gamma to reciprocally control their activities. Conclusion: PP5 is a switch point in nuclear receptor control of lipid metabolism. Significance: PP5 is a potential new drug target in the treatment of obesity.

引用

页码：42911 / 42922

页数：12

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