Protein Phosphatase 5 Mediates Lipid Metabolism through Reciprocal Control of Glucocorticoid Receptor and Peroxisome Proliferator-activated Receptor-γ (PPARγ)

被引：71
作者：
Hinds, Terry D., Jr. [1 ,2 ]
Stechschulte, Lance A. [1 ,2 ]
Cash, Harrison A. [1 ,2 ]
Whisler, Donald [1 ,2 ]
Banerjee, Ananya [1 ,2 ]
Yong, Weidong [3 ]
Khuder, Saja S. [1 ,2 ]
Kaw, Meenakshi K. [1 ,2 ]
Shou, Weinian [3 ]
Najjar, Sonia M. [1 ,2 ]
Sanchez, Edwin R. [1 ,2 ]
机构：
[1] Univ Toledo, Coll Med, Ctr Diabet & Endocrine Res, Toledo, OH 43614 USA
[2] Univ Toledo, Coll Med, Dept Physiol & Pharmacol, Toledo, OH 43614 USA
[3] Indiana Univ Sch Med, Dept Pediat, Herman B Wells Ctr Pediat Res, Pediat Cardiol Sect, Indianapolis, IN 46202 USA
来源：
JOURNAL OF BIOLOGICAL CHEMISTRY | 2011年 / 286卷 / 50期
基金：
美国国家卫生研究院;
关键词：
TETRATRICOPEPTIDE REPEAT DOMAIN; HEAT-SHOCK-PROTEIN; ADIPOCYTE DIFFERENTIATION; TRANSCRIPTIONAL ACTIVITY; ADIPOSE-TISSUE; SERINE/THREONINE PHOSPHATASE; IMMUNOPHILIN FKBP51; STEROID-RECEPTORS; SQUIRREL-MONKEY; MESSENGER-RNA;
D O I：
10.1074/jbc.M111.311662
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Background: The glucocorticoid (GR) and peroxisome proliferator-activated (PPAR gamma) receptors are antagonists of lipid metabolism. Results: Protein phosphatase 5 (PP5) dephosphorylates GR and PPAR gamma to reciprocally control their activities. Conclusion: PP5 is a switch point in nuclear receptor control of lipid metabolism. Significance: PP5 is a potential new drug target in the treatment of obesity.
引用
收藏
页码：42911 / 42922
页数：12
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