Chronic urticaria: a comparison of management guidelines

被引:10
作者
Ortonne, Jean-Paul [1 ]
机构
[1] Hop Archer, Serv Dermatol, F-06202 Nice 03, France
关键词
antihistamines; chronic urticaria; expert opinion; management guidelines; second-generation; uptitration; CHRONIC IDIOPATHIC URTICARIA; QUALITY-OF-LIFE; DESLORATADINE; 5; MG; LEUKOTRIENE RECEPTOR ANTAGONIST; CHRONIC AUTOIMMUNE URTICARIA; SERUM SKIN-TEST; DOUBLE-BLIND; THERAPEUTIC ALTERNATIVES; PLACEBO; CETIRIZINE;
D O I
10.1517/14656566.2011.629189
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Introduction: Chronic urticaria is characterized by recurring episodes of spontaneous transient dermal wheals and pruritus, with or without angioedema, which can persist for 6 weeks. Chronic urticaria impairs quality of life, emphasizing the need for effective treatments. Professional societies and clinical experts have issued evidence-based recommendations for the management of chronic urticaria, including recommending the use of second-generation antihistamines as a first-line therapy. Areas covered: A Medline search was conducted from 2000 to 2011 using the following terms, alone or in combination: 'chronic urticaria', 'management guidelines', 'consensus guidelines' and 'expert opinions'. Ten management guidelines/expert opinions met the inclusion criteria. Expert opinion: There was a universal agreement among the articles reviewed, that low-sedating, second-generation antihistamines should be prescribed as a first-line treatment of chronic urticaria. For refractory urticaria, however, recommendations varied and included dose escalation of second-generation antihistamines and adjunctive treatments with other agents of the same class, such as sedating antihistamines or leukotriene receptor antagonists. More research into effective second-line treatments and consistent implementation of current guidelines is needed, to ensure that treatment is based on clinical evidence.
引用
收藏
页码:2683 / 2693
页数:11
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