Imatinib stimulates prostaglandin E2 and attenuates cytokine release via EP4 receptor activation

被引：12

作者：

Baernthaler, Thomas ^{[1
]}

Jandl, Katharina ^{[2
]}

Sill, Heinz ^{[3
]}

Uhl, Barbara ^{[3
]}

Schreiber, Yannick ^{[4
]}

Grill, Magdalena ^{[1
]}

Thomas, Dominique ^{[5
]}

Schicho, Rudolf ^{[1
,6
]}

Marsche, Gunther ^{[1
,6
]}

Frank, Sasa ^{[7
]}

Heinemann, Akos ^{[1
,6
]}

Schuligoi, Rufina ^{[1
]}

机构：

[1] Med Univ Graz, Div Pharmacol, Otto Loewi Res Ctr, Graz, Austria

[2] Ludwig Boltzmann Inst Lung Vasc Res, Graz, Austria

[3] Med Univ Graz, Div Hematol, Dept Internal Med, Graz, Austria

[4] Fraunhofer Inst Mol Biol & Appl Ecol IME, Project Grp TMP, Frankfurt, Germany

[5] Goethe Univ Frankfurt, Pharmazentrum Frankfurt ZAFES Inst Clin Pharmacol, Frankfurt, Germany

[6] BioTechMed, Graz, Austria

[7] Med Univ Graz, Div Mol Biol & Biochem, Gottfried Schatz Res Ctr, Graz, Austria

来源：

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | 2019年 / 143卷 / 02期

基金：

奥地利科学基金会;

关键词：

INHIBITION; PHARMACOKINETICS;

D O I：

10.1016/j.jaci.2018.09.030

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

[No abstract available]

引用

页码：794 / +

页数：20

共 17 条

[1] Inhibition of carrageenan-induced edema by indomethacin or sodium salicylate does not prevent the increase of nerve growth factor in the rat hind paw [J].

Amann, R ;

Schuligoi, R .

NEUROSCIENCE LETTERS, 2000, 278 (03) :173-176

[2] The Role of PGE2 in Alveolar Epithelial and Lung Microvascular Endothelial Crosstalk [J].

Barnthaler, Thomas ;

Maric, Jovana ;

Platzer, Wolfgang ;

Konya, Viktoria ;

Theiler, Anna ;

Hasenohrl, Carina ;

Gottschalk, Benjamin ;

Trautmann, Sandra ;

Schreiber, Yannick ;

Graier, Wolfgang F. ;

Schicho, Rudolf ;

Marsche, Gunther ;

Olschewski, Andrea ;

Thomas, Dominique ;

Schuligoi, Rufina ;

Heinemann, Akos .

SCIENTIFIC REPORTS, 2017, 7

[3] KIT Inhibition by Imatinib in Patients with Severe Refractory Asthma [J].

Cahill, Katherine N. ;

Katz, Howard R. ;

Cui, Jing ;

Lai, Juying ;

Kazani, Shamsah ;

Crosby-Thompson, Allison ;

Garofalo, Denise ;

Castro, Mario ;

Jarjour, Nizar ;

DiMango, Emily ;

Erzurum, Serpil ;

Trevor, Jennifer L. ;

Shenoy, Kartik ;

Chinchilli, Vernon M. ;

Wechsler, Michael E. ;

Laidlaw, Tanya M. ;

Boyce, Joshua A. ;

Israel, Elliot .

NEW ENGLAND JOURNAL OF MEDICINE, 2017, 376 (20) :1911-1920

[4]

Fava Carmen, 2009, Drug Des Devel Ther, V2, P233

[5] Human Langerhans-cell activation triggered in vitro by conditionally expressed MKK6 is counterregulated by the downstream effector RelB [J].

Joergl, Almut ;

Platzer, Barbara ;

Taschner, Sabine ;

Heinz, Leonhard X. ;

Hoecher, Bernhard ;

Reisner, Peter M. ;

Goebel, Florian ;

Strobl, Herbert .

BLOOD, 2007, 109 (01) :185-193

[6] E-type prostanoid receptor 4 (EP4) in disease and therapy [J].

Konya, Viktoria ;

Marsche, Gunther ;

Schuligoi, Rufina ;

Heinemann, Akos .

PHARMACOLOGY & THERAPEUTICS, 2013, 138 (03) :485-502

[7] Myeloproliferative neoplasms and inflammation: whether to target the malignant clone or the inflammatory process or both [J].

Koschmieder, S. ;

Mughal, T. I. ;

Hasselbalch, H. C. ;

Barosi, G. ;

Valent, P. ;

Kiladjian, J-J ;

Jeryczynski, G. ;

Gisslinger, H. ;

Jutzi, J. S. ;

Pahl, H. L. ;

Hehlmann, R. ;

Vannucchi, A. Maria ;

Cervantes, F. ;

Silver, R. T. ;

Barbui, T. .

LEUKEMIA, 2016, 30 (05) :1018-1024

[8] IDENTIFICATION OF AN ENZYME IN PLATELET MICROSOMES WHICH GENERATES THROMBOXANE-A-2 FROM PROSTAGLANDIN ENDOPEROXIDES [J].

NEEDLEMAN, P ;

MONCADA, S ;

BUNTING, S ;

VANE, JR ;

HAMBERG, M ;

SAMUELSSON, B .

NATURE, 1976, 261 (5561) :558-560

[9]

Patrignani P, 1997, J PHYSIOL PHARMACOL, V48, P623

[10] Clinical pharmacokinetics of imatinib [J].

Peng, B ;

Lloyd, P ;

Schran, H .

CLINICAL PHARMACOKINETICS, 2005, 44 (09) :879-894

← 1 2 →